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Using primary mouse model of soft-tissue sarcoma (STS), authors show that sarcoma switches to glutamine metabolism post radiation therapy, and inhibition of glutaminolysis, either via genetic or pharmacological alterations, radiosensitizes STS in vivo.
Skeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.
A GWAS on 500 genetically diverse rice accessions enables identification of an allelic series for the unusual Ptr rice blast resistance gene, and the Pia resistance locus.
QUINT workflow analysis of cell and amyloid density in AD-BXD mice demonstrates age-dependent and strain-specific increases in gliosis and amyloid accumulation. These changes in brain composition influence age-related variations in gene expression.
A genome-wide association study on knee extension strength in 3452 persons of Japanese ancestry 60 years old and above identifies a significant association at a single locus that includes TACC2, a gene encoding a cytoskeleton-related protein.
An RNA sequencing study comparing juvenile cattle horn buds to growing deer antler tissues finds gene expression patterns that support homology of horns and antlers relative to a cranial-appendage-lacking outgroup.
Amplification in liposarcoma develops through a stepwise process that does not fit with classical chromothripsis. Depending on if and when telomeres from other chromosomes are captured, circularized or linear gain of 12q sequences will predominate.
Infant gray mouse lemurs performed better when they were born to mothers fed with dairy fat vs. vegetable fat in a set of tasks involving motor synchronization, sensory perception, learning and memory, suggesting an earlier psychomotor and cognitive development.
We analyzed the organ of Corti motions, component by component. Outer hair cells exploit their supporting cells to boost vibrations of the upper part of the organ of Corti while minimally disturbing the basilar membrane.
Dynamic processes of bacterial genome amplification involving a non-replicable but inheritable circular DNA molecule encoding multiple drug resistance proteins.
A study suggests that TBC9, one of the Rab GTPase Activating Proteins, is crucial for early vesicular transport and inner membrane complex formation by regulating Rab2, Rab11A and Rab11B in Toxoplasma gondii.
Dynamic mode decomposition captures spatiotemporal patterns in neural activity such as human electrocorticographic signals. This study presents a novel method for vectorising the dynamic modes to increase the speed and accuracy of neural decoding.
Brain endothelial cells activate EGFR signaling in triple-negative breast cancer cells, promoting brain metastasis. DOCK4 is crucial for cancer cell extravasation to the brain, with EGFR activation driving cell elongation reversed by Afatinib.
This study demonstrates that adult zebra finches maintain song performance by preventing song changes through physical act of daily singing throughout their life.
This study presents the essential functions of the ZnF motif in sorting of the melanophilin protein and novel functions of melanophilin in dendritogenesis in melanocytes.
Designing a supervised latent factor framework for snRNA-seq human brain, the authors find distinct Alzheimer’s-predictive gene modules across celltypes, suggesting subcelltype disease progression trajectories.
Signal transducer and activator of transcription (STAT) is kept in an activated state in non-small cell lung cancer cells (NSCLC) through PRMT5 methylation, which also controls STAT’s transcriptional activity and tumour growth and cancer stem cell maintenance support.
ADAR2 KO mice are protected against several HFD–induced metabolic defects, show reduced hepatic lipid accumulation, improved hepatic insulin signaling, and increased pyruvate tolerance and glycogen synthesis, by activation of AMPK signaling pathways.