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This review discusses recent advances demonstrating the role of replication stress as an ultimate driver of cellular senescence and aging, highlighting connections to hallmarks of aging, hereditary accelerated aging disorders, and senotherapeutics.
A review synthesizes interplays between photoperiodism and circadian regulation of the vegetative to reproductive transition in Arabidopsis and crops in responses to changing day lengths that ensures optimal timing for flowering and seed production.
Nucleic acids-based drugs aim to fix the genetic problem at its source and emerge as a promising new class of drugs. Recent advances in this field enabled their approval for the treatment of orphan genetic diseases for which no cure was available.
A review summarizes how ATG7 is precisely programmed by genetic, transcriptional, and epigenetic modifications in cells and its functions, including the relationship between ATG7 and aging-related diseases.
This review introduces the basic principle of fluorescence and two-photon excitation microscopy that is aimed at novice and advanced microscopists highlighting current techniques, trends, and practical guides for live imaging optimization.
The snake venom toxins responsible for tissue damage, their mechanisms of action and pathological effects are reviewed, together with the search of novel therapeutic alternatives to abrogate their effects
An in-depth review compiling information about the effects of virus infections in protists and discussing how these interactions are important for cell biology, ecology and biotechnology.
The subthalamic nucleus is a highly evolutionary conserved brain region. Emerging studies reveal spatio-molecular heterogeneity leading to improved understanding of the organization of the STN and targeting for specific neurological disorders.
This review discusses the challenges and opportunities of fMRI connectivity mapping across species and highlights a set of general principles governing the organization of mammalian connectivity networks.
Numerous unicellular eukaryotes host algal endosymbionts or utilize chloroplasts sequestrated from algal prey. They have developed some mechanisms to mitigate photosynthetic oxidative stress which are similar to those employed by algae and plants.
A high-level perspective on the future of live imaging is presented, with a vision to image anything in a biological sample, anywhere and at any time. A particular focus is given to current challenges and strategies to overcome them.
This review highlights the regulation of three major specialized metabolite biosynthesis pathways in plants by light-responsive gene expression, microRNA regulation, and posttranslational modification of regulatory proteins.
This review discusses the intricate interactions between rhizobacterial consortia-based inoculants, cropping systems, and soil abiotic stresses, focusing specifically on drought and phosphorous deficiency.