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This article collection focuses on mineralocorticoids in human hypertension. Mineralocorticoids’ importance in blood pressure regulation is highlighted by altered mineralocorticoid activity--or simulacra of altered mineralocorticoid activity--in monogenic disorders of hypertension. Primary aldosteronism is the most common form of secondary hypertension and this condition of inappropriate mineralocorticoid secretion is present in approximately 20% of patients with resistant hypertension.