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Tumors are not isolated islands of cells but reside within a microenvironment with multiple other cell types that affect tumor development, progression, and treatment. The tumor-infiltrating immune cells are some of the most important cells in this milieu. They are also among the most diverse, and their roles in regulating the tumor vary dependent upon their cell type. Much effort has focused on understanding the different immune cell subsets, including their activation state, localization, and potential as prognostic and theragnostic biomarkers. However, the optimal methods for characterizing these subsets are still unclear.
This Collection invites original research on tumor-infiltrating immune cells, including new methods for characterizing different subsets and investigations into their different functional roles.