Focus
Focus on RNA Silencing
Since initial observations indicating that small RNAs can mediate silencing, this phenomenon has come to be recognized as a key means of gene regulation, participating in a variety of processes across species. Still, research into small RNA-mediated regulation and the scope of this regulation, as well as its role in disease, continues to yield new insights and surprises. The NSMB Web Focus on RNA silencing comprises a core collection encompassing a specially commissioned Perspective and recently published Research Articles covering a range of current topics in the field. The broader Nature Research library brings together additional recent advances in the field published at NSMB and other Nature journals.
Current Research
Allosteric regulation of Argonaute proteins by miRNAs-
Sergej Djuranovic, Michelle Kim Zinchenko, Junho K Hur, Ali Nahvi, Julie L Brunelle, Elizabeth J Rogers & Rachel Green
Nature Structural & Molecular Biology 17, 144-150
doi:10.1038/nsmb.1736
Comprehensive discovery of endogenous Argonaute binding sites in C. elegans-
Dimitrios G Zisoulis, Michael T Lovci, Melissa L Wilbert, Kasey R Hutt, Tiffany Y Liang, Amy E Pasquinelli & Gene W Yeo
Nature Structural & Molecular Biology 17, 173-179
doi:10.1038/nsmb.1745
Loqs and R2D2 act sequentially in the siRNA pathway in Drosophila-
João Trindade Marques, Kevin Kim, Pei-Hsuan Wu, Trevis M Alleyne, Nadereh Jafari & Richard W Carthew
Nature Structural & Molecular Biology 17, 24 - 30 (2010)
doi:10.1038/nsmb.1735
Structural insights into RNA processing by the human RISC-loading complex-
Hong-Wei Wang, Cameron Noland, Bunpote Siridechadilok, David W Taylor, Enbo Ma, Karin Felderer, Jennifer A Doudna & Eva Nogales
Nature Structural & Molecular Biology 16, 1148 - 1153 (2009)
doi:10.1038/nsmb.1673
Perspective
MicroRNA assassins: factors that regulate the disappearance of miRNAs-
Zoya S Kai and Amy E Pasquinelli
Nature Structural & Molecular Biology 17, 5 10 (2010)
doi:10.1038/nsmb.1762
Editorial
Focusing in on the small-
Nature Structural & Molecular Biology 17, 1 (2010)
doi:10.1038/nsmb0110-1
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