![Film splicing (as a metaphor for RNA splicing)](https://media.springernature.com/w735h400/nature-cms/uploads/cms/pages/5337/top_item_image/05_NSMB-Hero-MAY24-a7ae7ad35c948193cecefcadb3668dc5.jpg)
Mechanisms of RNA processing and splicing
In this issue, we feature studies on RNA processing, including mechanisms of mRNA splicing, biogenesis of the splicing machinery, mRNA decoding by the ribosome, and mRNA deadenylation for degradation.
In this issue, we feature studies on RNA processing, including mechanisms of mRNA splicing, biogenesis of the splicing machinery, mRNA decoding by the ribosome, and mRNA deadenylation for degradation.
An iron-induced ferroptosis screen revealed PRDX6 as a selenoprotein-synthesis factor. Loss of PRDX6 substantially decreased expression of the selenoprotein GPX4, a master regulator of ferroptosis, and induced ferroptosis. Mechanistically, PRDX6 increases the efficiency of selenium use by acting as a selenium delivery protein.