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Fluorescent probe-based techniques have been recognized as one of the most powerful tools for real-time imaging and sensing in biological samples. They can detect biological species, such as metal ions, reactive sulfur, oxygen species and metabolites, and probe the cellular microenvironment, by measuring pH, oxygen levels or viscosity. Numerous types of fluorescence agents have been developed, including organic, nano, supramolecular, polymeric fluorophores, and more. Through effective design strategies and by regulating the electronic and spectral characteristics of the fluorescent platforms, chemical probes can attain high selectivity and perform a wide range of functions. As such, fluorescent probes have been developed to allow for enhanced tissue penetration and spatial resolution, reduced scattering and autofluorescence, high photostability, as well as multi-modal imaging and multi-organelle-targeting.
This Collection aims to offer insights and inspiration for the development of fluorescent probes for biological imaging and sensing. We encourage submissions that focus on design strategies and rational response mechanisms, electronic and spectral characteristics, and biological applications as powerful tools for chemical biology. We welcome both fundamental and applied studies, as well as both experimental and theoretical research.
The Collection primarily welcomes original research papers, and we encourage submissions from all authors—and not by invitation only.
This Collection supports and amplifies research related to SDG 3.