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It is the age of large biobanks in human genetics. This Collection brings together primary research articles and related content that describe and utilize data from FinnGen, a research project that combines longitudinal electronic health records from Finnish health registries with genotyping data. As an isolated population, Finns have a more homogenous genetic make-up than others, and rare and low frequency genetic variants can reach comparably high frequency at the population level. This gives researchers unique opportunities to identify novel genetic associations for diseases that would be difficult or impossible to detect in other populations.