Correction to: Nature https://doi.org/10.1038/s41586-021-03448-9 Published online 12 May 2021
The key reagents used in this study for nitrogen deletion belong to a class of compounds (N-acyloxy-N-alkoxyamides), some of which have been shown to mutate genetic material. We are currently investigating the mutagenicity of 1c; as this is currently not known, we advise that 1c should be used with appropriate caution. Please see Banks et al.1 and references therein for predictive quantitative structure activity relationships for the mutagenicity of N-acyloxy-N-alkoxyamides. We thank Stephen Glover for raising this safety concern.
Further, in the legend to Fig. 3b, now reading “b2 equivalents triethylamine were added,” there was a typographical error (“trimethylamine”) in the version originally published; the change has been made in the HTML and PDF versions of the article.
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10 August 2022
In the version of this amendment initially published, there was a typo in Stephen Glover’s name, which has now been corrected.
References
Banks, T. M., Clay, S. F., Glover, S. A. & Schumacher, R. R. Mutagenicity of N-acyloxy-N-alkoxyamides as an indicator of DNA intercalation part 1: evidence for naphthalene as a DNA intercalator. Org. Biomol. Chem. 14, 3699–3714 (2016).
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Kennedy, S.H., Dherange, B.D., Berger, K.J. et al. Author Correction: Skeletal editing through direct nitrogen deletion of secondary amines. Nature 608, E11 (2022). https://doi.org/10.1038/s41586-022-05000-9
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DOI: https://doi.org/10.1038/s41586-022-05000-9
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