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Osteoarthritis

Understanding synovial cell diversity in post-traumatic OA

Nature Reviews Rheumatology volume 19, pages 4–5 (2023)Cite this article

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Research related to the role of the synovium and its cell constituents during the pathogenies of osteoarthritis (OA) has taken a back seat to that of the cartilage and chondrocytes. The influence of synoviocytes in OA is increasingly recognized, but are synoviocytes equal in their contributions to disease progression?

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Fig. 1: Potential Wnt-induced, synovial fibroblast-mediated mechanisms contributing to post-traumatic osteoarthritis (PTOA) pathogenesis.

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Authors and Affiliations

  1. Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada

    Jason S. Rockel & Mohit Kapoor

  2. Krembil Research Institute, University Health Network, Toronto, ON, Canada

    Jason S. Rockel & Mohit Kapoor

  3. Department of Laboratory Medicine and Pathobiology and Department of Surgery, University of Toronto, Toronto, ON, Canada

    Mohit Kapoor

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  1. Jason S. Rockel
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  2. Mohit Kapoor
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Correspondence to Mohit Kapoor.

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Rockel, J.S., Kapoor, M. Understanding synovial cell diversity in post-traumatic OA. Nat Rev Rheumatol 19, 4–5 (2023). https://doi.org/10.1038/s41584-022-00876-3

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