Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Commentary on: “Oxycodone prescription after inflatable penile prosthesis has risks of persistent use: a TriNetX Analysis”

International Journal of Impotence Research (2023)Cite this article

Subjects

Despite efforts by healthcare providers to decrease prescriptions, the number of opioid related deaths over the past several years has continued to increase [1]. Research efforts amongst urologists across many sub-specialties have demonstrated that post-operative opioid prescriptions significantly increase the risk of developing persistent opioid use disorder, defined as receiving an additional opioid prescription after 3 to 9 months of the initial index prescription [2,3,4]. Prebay et al expanded upon this previous literature by further demonstrating this risk in reconstructive urology for patients following inflatable penile prosthesis placement [5].

Through the use of the TriNetX Research database, an insurance claims database incorporating 78 healthcare organizations and 110 million patients, the authors were able to compare 7000 patients that received an oxycodone prescription to a matched cohort consisting of patients that did not receive an oxycodone prescription. While there is no way to determine if these patients are opioid-naive, the results demonstrated that men that received a hydrocodone prescription with 1.9 times more likely to receive an opioid prescription within 9 to 15 months of the index prescription.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Data availability

Data regarding any of the subjects in the study has not been previously published. Available data will be made available to the editors of the journal for review or query upon request.

References

  1. Opioid Overdose | Drug Overdose | CDC Injury Center. 2023 Accessed 4 Sep 2023. https://www.cdc.gov/drugoverdose/deaths/opioid-overdose.html.

  2. Able CA, Gabrielson AT, Meilchen C, Kohn JR, Kohn TP. Perioperative opioid prescribing after male fertility procedures is associated with new persistent opioid use: retrospective analysis of a large claims database. Fertil Steril. 2023;119:401–408. https://doi.org/10.1016/j.fertnstert.2022.12.015. Epub 2022 Dec 16.

  3. Grutman AJ, Stewart C, Able C, Agrawal P, Galansky L, Gabrielson A, Haney N, Kohn TP, Crigger CB. Postoperative Opioid Prescribing in Adolescents and Young Adults After Urologic Procedures is Associated with New Persistent Opioid Use Disorder - A Large Claims Database Analysis. Urology. 2023:S0090-4295(23)00778-1. https://doi.org/10.1016/j.urology.2023.08.031. Epub ahead of print.

  4. Namiranian K, Siglin J, Sorkin JD. The incidence of persistent postoperative opioid use among U.S. veterans: A national study to identify risk factors. J Clin Anesth. 2021;68:110079.

    Article  CAS  PubMed  Google Scholar 

  5. Prebay ZJ, Foss H, Ebbott D, Li M, Chung PH. Oxycodone prescription after inflatable penile prosthesis has risks of persistent use: a TriNetX analysis. Int J Impot Res. 2023. https://doi.org/10.1038/s41443-023-00760-y. Epub ahead of print.

  6. Sayyid RK, Taylor NS, Owens-Walton J, Oberle MD, Fratino KL, Terris MK, et al. Pudendal nerve block prior to inflatable penile prosthesis implantation: decreased intra-operative narcotic requirements. Int J Impot Res. 2023;35:1–5.

    Article  CAS  PubMed  Google Scholar 

  7. Tong CMC, Lucas J, Shah A, Foote C, Simhan J. Novel Multi-Modal Analgesia Protocol Significantly Decreases Opioid Requirements in Inflatable Penile Prosthesis Patients. J Sex Med. 2018;15:1187–94.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Urology, Department of Surgery, University of Texas Medical Branch School of Medicine, Galveston, TX, USA

    Corey Able

  2. The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Pranjal Agrawal & Taylor P. Kohn

Authors
  1. Corey Able
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pranjal Agrawal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Taylor P. Kohn
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

CA: Manuscript writing, concept generation, revising. PA: Manuscript writing, concept generation, revising. TPK: Manuscript writing, concept generation, revising.

Corresponding author

Correspondence to Corey Able.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Able, C., Agrawal, P. & Kohn, T.P. Commentary on: “Oxycodone prescription after inflatable penile prosthesis has risks of persistent use: a TriNetX Analysis”. Int J Impot Res (2023). https://doi.org/10.1038/s41443-023-00778-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41443-023-00778-2

Search

Advanced search

Quick links