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Characterization of adenosine A2 receptors in peripheral blood mononuclear cells of patients with fibromuscular dysplasia

Hypertension Research volume 43, pages 466–469 (2020)Cite this article

Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory vascular disease characterized by unexplained systemic hypertension in patients under the age of 35, migraine-like headaches, epigastric or cervical bruit, arterial stenosis, aneurysm rupture, intracranial/renal infarction, renal damage and stroke [1, 2].

Although the gold standard for diagnosis remains catheter angiography, biological markers would be helpful, as the delay from first symptom to diagnosis is long. It is notable that most patients are females [1], which is in agreement with the high expression of progesterone receptors in renovascular FMD [3].

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Acknowledgements

Aix Marseille University and AP-HM for financial help.

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Author notes

  1. These authors contributed equally: François Silhol, Marion Marlinge, Claire Guiol, Régis Guieu, Emmanuel Fenouillet

Authors and Affiliations

  1. Hypertension Department, Pôle Cardio-Vasculaire, Hôpital de la Timone 264 Avenue Saint-Pierre, 13385, Marseille cedex, France

    François Silhol, Bernard Vaisse & Gabrielle Sarlon

  2. Aix Marseille Université, INSERM, INRA, C2VN, Paris, France

    Marion Marlinge, Claire Guiol, Christine Criado, Nathalie Kipson, Donato Vairo, Jean Ruf, Laurie Bruzzese, Giovanna Mottola, Régis Guieu & Emmanuel Fenouillet

  3. Laboratory of Biochemistry, Hôpital de la Timone, Paris, France

    Marion Marlinge, Mohamed Chefrour, Patrick Mace & Régis Guieu

  4. Chronic Pain and Headache Centre, Hôpital de la Timone, Paris, France

    Anne Donnet & Régis Guieu

  5. Institut des Sciences Biologiques, CNRS, 75016, Paris, France

    Emmanuel Fenouillet

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Correspondence to François Silhol.

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Silhol, F., Marlinge, M., Guiol, C. et al. Characterization of adenosine A2 receptors in peripheral blood mononuclear cells of patients with fibromuscular dysplasia. Hypertens Res 43, 466–469 (2020). https://doi.org/10.1038/s41440-019-0379-3

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