This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Xiao Z, Wang S, Luo L, Lv W, Feng P, Sun Y, et al. Lkb1 orchestrates gd T cell metabolic and functional fitness to control IL-17 mediated autoimmune hepatitis. Cell Mol Immunol. 2024;21:546–60.
Chien YH, Meyer C, Bonneville M. γδ T cells: first line of defense and beyond. Annu Rev Immunol. 2014;32:121–55.
Muñoz-Ruiz M, Sumaria N, Pennington DJ, Silva-Santos B. Thymic determinants of γδ T cell differentiation. Trends Immunol. 2017;38:336–44.
Parker ME, Ciofani M. Regulation of γδ T cell effector diversification in the thymus. Front Immunol. 2020;11:42.
Ashby KM, Hogquist KA. A guide to thymic selection of T cells. Nat Rev Immunol. 2024;24:103–17.
Zhang M, Lin X, Yang Z, Li X, Zhou Z, Love PE, et al. Metabolic regulation of T cell development. Front Immunol. 2022;13:946119.
Wilfahrt D, Delgoffe GM. Metabolic waypoints during T cell differentiation. Nat Immunol. 2024;25:206–17.
Bourouh M, Marignani PA. The tumor suppressor kinase LKB1: metabolic nexus. Front Cell Dev Biol. 2022;10:881297.
Chen X, Morrissey S, Chen F, Yan J. Novel insight into the molecular and metabolic mechanisms orchestrating IL-17 production in γδ T cells. Front Immunol. 2019;10:2828.
Chen X, Cai Y, Hu X, Ding C, He L, Zhang X, et al. Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans. Sci Adv. 2022;8:eabm9120.
Funding
This work was supported by American Heart Association predoctoral fellowship 24PRE1191939 (to YW), the National Institutes of Health grant RO1AI139046 (to LVK), and the American Heart Association grant 19TPA34910078 (to LVK).
Author information
Authors and Affiliations
Contributions
Yiwen Wang reviewed and edited the text and made the figure; Lan Wu reviewed and edited the text; Luc Van Kaer wrote the first draft and reviewed and edited the text.
Corresponding author
Ethics declarations
Competing interests
LVK is a member of the scientific advisory board of Isu Abxis Co., Ltd. (South Korea). The other authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Wang, Y., Wu, L. & Van Kaer, L. Liver kinase B1 (LKB1) staves off γδ T-cell-mediated autoimmune liver disease. Cell Mol Immunol 21, 641–642 (2024). https://doi.org/10.1038/s41423-024-01172-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41423-024-01172-8