Sir, recent studies have indicated that periodontal pathogens that are present in the oral cavity and can enter the bloodstream through the oropharyngeal port have the potential to cross the blood-brain barrier and potentially accelerate Alzheimer's disease (AD)-specific neuropathology. This acceleration occurs through increased neuroinflammation, plaque formation, and dysregulation of iron homeostasis, ultimately leading to ferroptosis, neuronal death, and neurodegeneration.1,2

It is disconcerting to note that the use of removable dentures (RDs) over time can lead to an increased presence of these bacteria.3,4 Furthermore, in patients with poor oral hygiene, RDs can also serve as a source of infection.4

Given the relatively higher prevalence of RDs use among elderly patients and the fact that AD often occurs in this age group, it is imperative to conduct comprehensive research to establish any potential link between these two factors.

Therefore, in today's ageing society, the identification and characterisation of modifiable risk factors associated with AD, including RDs, have the potential to significantly reduce its prevalence. In addition, prosthodontists must place patient safety as a top priority and guarantee that prosthetic treatments are both efficient and safe for extended periods.