This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pohl C, Dikic I. Cellular quality control by the ubiquitin-proteasome system and autophagy. Science. 2019;366:818–22.
Wang X, Meul T, Meiners S. Exploring the proteasome system: a novel concept of proteasome inhibition and regulation. Pharmacol Ther. 2020;211:107526.
Hayashi T, Horiuchi A, Sano K, Hiraoka N, Kanai Y, Shiozawa T, et al. Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma. Protein Cell. 2010;1:711–7.
Chen X, Mao Y, Guo Y, Xiao D, Lin Z, Huang Y, et al. LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions. J Transl Med. 2023;21:226.
Krause S. Immunoproteasome subunit LMP2 expression is deregulated in Sjogren’s syndrome but not in other autoimmune disorders. Ann Rheum Dis. 2006;65:1021–7.
Li S, He RC, Wu SG, Song Y, Zhang KL, Tang ML, et al. LncRNA PSMB8-AS1 instigates vascular inflammation to aggravate atherosclerosis. Circ Res. 2023;134:60–80.
Liao J, Xie Y, Lin Q, Yang X, An X, Xia Y, et al. Immunoproteasome subunit beta5i regulates diet-induced atherosclerosis through altering MERTK-mediated efferocytosis in Apoe knockout mice. J Pathol. 2020;250:275–87.
Liao J, An X, Yang X, Lin QY, Liu S, Xie Y, et al. Deficiency of LMP10 attenuates diet-induced atherosclerosis by inhibiting macrophage polarization and inflammation in apolipoprotein E deficient mice. Front Cell Dev Biol. 2020;8:592048.
Pichavaram P, Mani AM, Singh NK, Rao GN. Cholesterol crystals promote endothelial cell and monocyte interactions via H2O2-mediated PP2A inhibition, NFkappaB activation and ICAM1 and VCAM1 expression. Redox Biol. 2019;24:101180.
Chen XY, Wan SF, Yao NN, Lin ZJ, Mao YG, Yu XH, et al. Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood-brain barrier injury through the Wnt/beta-catenin signalling pathway. Mil Med Res. 2021;8:62.
Chen B, Zhu H, Yang B, Cao J. The dichotomous role of immunoproteasome in cancer: Friend or foe? Acta Pharm Sin B. 2023;13:1976–89.
Hewing B, Ludwig A, Dan C, Pötzsch M, Hannemann C, Petry A, et al. Immunoproteasome subunit β5i/LMP7-deficiency in atherosclerosis. Sci Rep. 2017;7:13342.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Liu, X., Delgado, E. A novel role of PSMB9 in endothelial cells and atherosclerosis: beyond its canonical function in immunoproteasome. Acta Pharmacol Sin (2024). https://doi.org/10.1038/s41401-024-01267-y
Received:
Accepted:
Published:
DOI: https://doi.org/10.1038/s41401-024-01267-y