Abstract
Thyroid function was evaluated in 28 (15 prepubertal and 13 pubertal) clinically euthyroid children with C.H. on 1-14 treatment. patients were divided in two groups (A=suppressed and B=not suppressed) according to their FSH response to FRH i.v. 20 prepubertal and 30 pubertal normal children served as control group (c). 14, 13, F14, and r13 have been measured by RIA, TSH by IRMA. All results are expressed as x±SD. In the prepubertal group, 8 had suppressed ISH to irh (Δ ISH < 4 uu/ml) and 7 normal (Δ ISH =4-16 uu/ml); in the pubertal group 7 were suppressed and 6 normal. L - 14 therapeutic regimen was identical in both A and B group (2.9±0.8 vs.2.9±0.7 μg/kg/day). ISH serum levels were lower (p < 0.01 ) in group A (0.3±0.3 μU/ml) compared to both group B (2.7±1.5) and C (2.9±1.4). In all C.H. patients basal ISH was correlated (r = 0.8 p < 0.01) with ISH. In comparison to c, F14 was higher (p < 0.01) in group A (13.8±2.2 vs.9.7±1.9 pg/ml) whereas 13/14 index was lower (p<0.01) both in group A and B (0.14±0.02 and 0.14±0.03 vs 0.2±0.04). In group A all prepubertal patients showed lower 13 and higher r13 levels (p<0.01) compared to the matched controls (1.4 ± 0.2 vs.1.7±0.2 and 0.4±0.1 vs.0.2±0.1 ng/ml). In conclusion, both ISH and P14, seem to be good parameters in monitoring overtreatment in C.H., although ISH appears more useful in the single case. Moreover particularly in prepuberty the peripheral monodeiodination in the first compensatory mechanism, present even in the absence of ISH suppression.
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Volta, C., Bernasconi, S., Davoli, A. et al. THYROID FUNCTION DURING L-14 THERAPY IN CHILDREN WITH CONGSNISAL HYPOTHYROIDISM (C.H.). Pediatr Res 23, 134 (1988). https://doi.org/10.1203/00006450-198801000-00195
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DOI: https://doi.org/10.1203/00006450-198801000-00195