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Connective tissue diseases

Functional MRI in SLE—the current state

Functional MRI (fMRI) is increasingly used in efforts to unravel the neuropathological processes of neuropsychiatric systemic lupus erythematosus (NPSLE). Standardization of scan protocols, imaging expertise and disease-related confounders of neuronal activities remain major challenges to the use of fMRI in the diagnosis and prognosis of NPSLE.

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Figure 1: Event-related functional MRI of the brains of patients with SLE and healthy controls during the learning paradigm of the Wisconsin card-sorting test.

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Acknowledgements

The authors' work is supported by the CS-IRG grant, National Medical Research Council, Singapore (R-172-000-337-511).

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Correspondence to Anselm Mak.

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The authors declare no competing financial interests.

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Supplementary Table 1

Summary of 10 fMRI studies in patients with SLE. (DOCX 34 kb)

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Mak, A., Tay, S. Functional MRI in SLE—the current state. Nat Rev Rheumatol 11, 686–687 (2015). https://doi.org/10.1038/nrrheum.2015.143

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