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Autoimmunity

Basophils in autoimmune and inflammatory diseases

Nature Reviews Rheumatology volume 11, pages 129–131 (2015)Cite this article

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Basophils are classically known for their pathogenic role in asthma and allergic skin conditions. However, reports suggest that basophil activation mediated by autoreactive IgE, thymic stromal lymphopoietin or Toll-like receptors has an important role in the pathogenesis of lupus nephritis, eosinophilic oesophagitis and IgG4-related diseases, respectively.

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Figure 1: Basophils in the pathogenesis of autoimmune and inflammatory diseases.

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Acknowledgements

The authors' research activities are supported by Institut National de le Santé et de la Recherche Médicale, Université Pierre et Marie Curie, Université Paris Descartes and the European Community's 7th Framework Programme (FP7/2007-2013) under Grant Agreement Number 260338-ALLFUN.

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  1. Institut National de la Santé et de la Recherche Médicale, Unité 1138, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médicine, Paris, F-75006, France

    Meenu Sharma & Jagadeesh Bayry

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  1. Meenu Sharma
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  2. Jagadeesh Bayry
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Correspondence to Jagadeesh Bayry.

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Sharma, M., Bayry, J. Basophils in autoimmune and inflammatory diseases. Nat Rev Rheumatol 11, 129–131 (2015). https://doi.org/10.1038/nrrheum.2014.199

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