Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

The promises and challenges of solid-state sequencing

Nature Nanotechnology volume 11, pages 109–111 (2016)Cite this article

Subjects

Sequencing methods based on electron tunnelling could lead to breakthroughs in genomics, proteomics and glycomics, but the engineering challenges involved in delivering these devices are formidable.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Three physical approaches to sequencing a moving DNA molecule.

References

  1. Church, G., Deamer, D. W., Branton, D., Baldarelli, R. & Kasianowicz, J. Characterization of individual polymer molecules based on monomer-interface interactions. US patent 5,795,782 (1998).

  2. Manrao, E. A. et al. Nature Biotechnol. 30, 349–353 (2012).

    Article  CAS  Google Scholar 

  3. Ip, C. L. C. et al. F1000Research 4, 1075 (2015).

    Article  Google Scholar 

  4. Heerema, S. J. & Dekker, C. Nature Nanotech. 11, 127–136 (2016).

    Article  CAS  Google Scholar 

  5. Di Ventra, M. & Taniguchi, M. Nature Nanotech. 11, 117–126 (2016).

    Article  CAS  Google Scholar 

  6. Hall, J. E. J. Gen. Physiol. 66, 531–532 (1975).

    Article  CAS  Google Scholar 

  7. Akahori, R. et al. Nanotechnology 25, 275501 (2014).

    Article  Google Scholar 

  8. Laszlo, A. H. et al. Nature Biotechnol. 32, 829–833 (2014).

    Article  CAS  Google Scholar 

  9. Jain, M. et al. Nature Methods 12, 351–356 (2015).

    Article  CAS  Google Scholar 

  10. Garaj, S. et al. Nature 467, 190–193 (2010).

    Article  CAS  Google Scholar 

  11. Zwolak, M. & Di Ventra, M. Nano Lett. 5, 421–424 (2005).

    Article  CAS  Google Scholar 

  12. Cui, X. D. et al. Science 294, 571–574 (2001).

    Article  CAS  Google Scholar 

  13. Chang, S. et al. Nanotechnology 23, 235101–235115 (2012).

    Article  Google Scholar 

  14. Chang, S., He, J., Zhang, P., Gyarfas, B. & Lindsay, S. J. Am. Chem. Soc. 133, 14267–14269 (2011).

    Article  CAS  Google Scholar 

  15. Pang, P. et al. ACS Nano 8, 11994–12003 (2014).

    Article  CAS  Google Scholar 

  16. Bai, J. et al. Nanoscale 6, 8900–8906 (2014).

    Article  CAS  Google Scholar 

  17. Cherf, G. M. et al. Nature Biotechnol. 30, 344–348 (2012).

    Article  CAS  Google Scholar 

  18. Fologea, D. et al. Nano Lett. 5, 1905–1909 (2005).

    Article  CAS  Google Scholar 

  19. Briggs, K. et al. Nanotechnology 26, 084004 (2015).

    Article  CAS  Google Scholar 

  20. Krishnakumar, P. et al. ACS Nano 7, 10319–10326 (2013).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported in part by the National Human Genome Research Institute (grant HG 006323), F. Hoffman La Roche and Recognition AnalytiX. Useful discussions with P. Pang, P. Zhang, B. Ashcroft and W. Song are acknowledged.

Author information

Authors and Affiliations

  1. Department of Physics and Department of Molecular Sciences, Stuart Lindsay is at the Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA,

    Stuart Lindsay

Authors
  1. Stuart Lindsay
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stuart Lindsay.

Ethics declarations

Competing interests

The author is a co-founder of Recognition AnalytiX, a company that holds the rights to applications of recognition tunnelling technology in the fields of proteomics and glycomics.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lindsay, S. The promises and challenges of solid-state sequencing. Nature Nanotech 11, 109–111 (2016). https://doi.org/10.1038/nnano.2016.9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nnano.2016.9

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing