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HIV tropism and CD4+ T-cell depletion

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References

  1. Grossman, Z. et al. CD4+ depletion in HIV infection: Are we closer to understanding the cause? Nature Med. 8, 319–323 (2002).

    Article  CAS  Google Scholar 

  2. Mohri, H. et al. Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiviral therapy. J. Exp. Med. 194, 1277–1287 (2001).

    Article  CAS  Google Scholar 

  3. Feinberg, M.B. et al. Nonpathogenic infections in animal models. 9th Conference on Retroviruses and Opportunistic Infection, Seattle, Abstract S24 (2002).

  4. Broussard, S.R. et al. Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease. J. Virol. 75, 2262–2275 (2001).

    Article  CAS  Google Scholar 

  5. Hazenberg, M.D. et al. T cell depletion in HIV-1 infection: How CD4+ T cells go out of stock. Nature Immunol. 1, 285–289 (2000).

    Article  CAS  Google Scholar 

  6. Berger, E.A., Murphy, P.M. & Farber, J.M. Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17, 657–700 (1999).

    Article  CAS  Google Scholar 

  7. Koot, M. et al. Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann. Intern. Med. 118, 681–688 (1993).

    Article  CAS  Google Scholar 

  8. Hazenberg M.D. et al. Deleterious effect of syncytium inducing (SI) CXCR4 using HIV-1 variants is directed at the thymus and the peripheral T cell pool. 9th Conference on Retroviruses and Opportunistic Infection, Seattle Abstract 338-W (2002).

  9. Su, L. et al. HIV-1 induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo. Immunity 2, 25–36 (1995).

    Article  CAS  Google Scholar 

  10. Blaak, H. et al. In vivo HIV-1 infection of CD45RA+CD4+ T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4+ T cell decline. Proc. Natl. Acad. Sci. USA 97, 1269–1274 (2000).

    Article  CAS  Google Scholar 

  11. Ostrowski, M.A. et al. Both memory and CD45RA+CD62L+ naive CD4+ T cells are infected in human immunodeficiency virus type 1-infected individuals. J. Virol. 73, 6430–6435 (1999).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. McCune, J.M. The dynamics of CD4+ T-cell depletion in HIV disease. Nature 410, 974–979 (2001).

    Article  CAS  Google Scholar 

  13. Hellerstein, M. et al. Kinetic subpopulations of T cells in humans: Effects of HIV-1 infection. 9th International Conference on Retroviruses and Opportunistic Infection, 86 (abstract 102).

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Hellerstein, M. HIV tropism and CD4+ T-cell depletion. Nat Med 8, 537–538 (2002). https://doi.org/10.1038/nm0602-537b

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