Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to the Editor
  • Published:

Reply to “Is EDRF a specific marker for TSEs?”

Nature Medicine volume 7, pages 641–642 (2001)Cite this article

Miele and Clinton reply

Although we chose to limit speculation on the mechanism underlying our recent findings1, we feel that the suggestion by Maury represents one of a number of reasonable interpretations. Maury is correct in stating that variation in the levels of circulating cytokines might affect the numbers of erythroid progenitor cells in bone marrow, although current evidence of induction of cytokines in scrapie-infected mice is limited to the central nervous system6,7.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Miele, G., Manson, J.C. & Clinton, M. A novel erythroid-specific marker of transmissible spongiform encehalopathies. Nature Med. 7, 361–364 (2001).

    Article  CAS  Google Scholar 

  2. Maury, C.P.J., Andersson, L.C., Teppo, A.M., Partanen, S. & Juvonen, E. Mechanism of anaemia in rheumatoid arthritis: demonstration of raised interleukin 1beta concentration in patients and of interleukin 1 mediated suppression of normal erythropoiesis and proliferation of human erythroleukaemia (HEL) cells in vitro. Ann. Rheum. Dis. 47, 972–978 (1988).

    Article  CAS  Google Scholar 

  3. Maury, C.P.J. & Teppo, A.M. Serum immunoreative interleukin 1 renal transplant recipients: association of raised levels with graft rejection episodes. Transplantation 45, 143–147 (1988).

    Article  CAS  Google Scholar 

  4. Maury, C.P.J., Salo, E. & Pelkonen, P. Circulating interleukin 1beta in patients with Kawasaki disease. N. Engl. J. Med. 319, 1670–1671 (1988).

    Article  CAS  Google Scholar 

  5. Maury, C.P.J. & Lahdevirta, J. Correlation of serum cytokine levels with hematological abnormalities in human immunodeficiency virus infection. J. Int. Med. 227, 253–257 (1990).

    Article  CAS  Google Scholar 

  6. Kim, J.L. et al. Expression of cytokine genes and increased nuclear factor-κB activity in the brains of scrapie-infected mice. Brain Res. Mol. Brain Res. 73, 17–27 (1999).

    Article  CAS  Google Scholar 

  7. Williams, A., VanDam, A.M., Ritchie, D., Eikelenboom, P. & Fraser, H. Immunocytochemical appearance of cytokines, prostaglandin E-2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations. Brain Res. 754, 171–180 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gene Expression & Development, Roslin Institute, Roslin, Midlothian, Scotland

    G. Miele & M. Clinton

Authors
  1. G. Miele
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Clinton
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miele, G., Clinton, M. Reply to “Is EDRF a specific marker for TSEs?”. Nat Med 7, 641–642 (2001). https://doi.org/10.1038/88973

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/88973

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing