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Reply to: "Paraoxonase-1 and clopidogrel efficacy"

Nature Medicine volume 17, pages 1042–1044 (2011)Cite this article

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Bouman et al. reply:

We very much appreciate the study of Cuisset et al.1 that complements our investigation2 and gives us the opportunity to focus on two issues: the relevance of differences in study design and the applied methodology for the observed outcomes; and the potential misinterpretation of our results as a clinical recommendation to tailor clopidogrel treatment on the basis of the PON1 genotype.

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Authors and Affiliations

  1. Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands

    Heleen J Bouman & Jochem W van Werkum

  2. Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands

    Heleen J Bouman, Jochem W van Werkum, Christian M Hackeng & Jurriën M ten Berg

  3. Department of Pharmacology, University Hospital of Cologne, Cologne, Germany

    Edgar Schömig & Dirk Taubert

  4. Department für Chemie, Universität zu Köln, Cologne, Germany

    Janna Velder, Christoph Hirschhäuser & Hans-Günther Schmalz

  5. Department of Clinical Chemistry, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands

    Christian M Hackeng

  6. Klinik und Poliklinik für Nuklearmedizin, Universität Münster, Münster, Germany

    Christopher Waldmann

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  1. Heleen J Bouman
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Correspondence to Dirk Taubert.

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Bouman, H., Schömig, E., van Werkum, J. et al. Reply to: "Paraoxonase-1 and clopidogrel efficacy". Nat Med 17, 1042–1044 (2011). https://doi.org/10.1038/nm.2469

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