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Reply to “Associations of CFHR1–CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent”

Nature Genetics volume 42, pages 555–556 (2010)Cite this article

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Hughes et al. reply:

The correspondence by Raychaudhuri et al.1 is in response to our publication in 2006 reporting that a common deletion of CFHR1 and CFHR3 is associated with lower risk of age-related macular degeneration (AMD)2. In both of these studies, many SNPs were genotyped in individuals with AMD and controls, and risk data based on haplotypes were presented. We are pleased to reply and discuss points relating to the interpretation of genetic association data in this complex genomic region that has high, but incomplete, linkage disequilibrium and contains several related genes in which variation may contribute to AMD risk.

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Author information

Authors and Affiliations

  1. Centre for Public Health, Queen's University, Belfast, Belfast, UK

    Anne E Hughes

  2. The Institute of Cancer Research, London, UK

    Nick Orr

  3. Institute of Human Genetics, Newcastle University, Newcastle, UK

    Heather J Cordell & Timothy Goodship

Authors
  1. Anne E Hughes
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  2. Nick Orr
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  3. Heather J Cordell
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  4. Timothy Goodship
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Corresponding author

Correspondence to Anne E Hughes.

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Competing interests

Queen's University Belfast (A.E.H.) holds a patent on protection against and treatment of age-related macular degeneration.

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Hughes, A., Orr, N., Cordell, H. et al. Reply to “Associations of CFHR1–CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent”. Nat Genet 42, 555–556 (2010). https://doi.org/10.1038/ng0710-555

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