Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Practice Point
  • Published:

Tissue plasminogen activator for acute ischemic stroke—is it for the elderly?

Nature Clinical Practice Neurology volume 4, pages 416–417 (2008)Cite this article

boxed-textGómez-Choco M et al. (2008) The response to IV rt-PA in very old stroke patients. Eur J Neurol 15: 253–256

Intravenous recombinant tissue plasminogen activator can be used for the treatment of acute ischemic stroke in the elderly (age ≥80 years) within the NINDS rtPA protocol

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333: 1581–1587

  2. Adams HP et al. (2007) Guidelines for the early management of adults with ischemic stroke. Stroke 38: 1655–1711

    Article  Google Scholar 

  3. The NINDS t-PA Stroke Study Group (1997) Generalized efficacy of t-PA for acute stroke: subgroup analysis of the NINDS t-PA Stroke Trial. Stroke 28: 2119–2125

  4. Tanne D et al. (2000) Intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 80 years and older: the tPA Stroke Survey experience. Stroke 31: 370–375

    Article  CAS  Google Scholar 

  5. Sylaja PN et al. (2006) Thrombolysis in patients older than 80 years with acute ischaemic stroke: Canadian Alteplase for Stroke Effectiveness Study. J Neurol Neurosurg Psychiatry 77: 826–829

    Article  CAS  Google Scholar 

  6. Berrouscho J et al. (2005) Outcome and severe hemorrhagic complications of intravenous thrombolysis with tissue plasminogen activator in very old (≥80 years) stroke patients. Stroke 36: 2421–2425

    Article  Google Scholar 

Download references

Acknowledgements

The synopsis was written by James Casey, Editorial Assistant, Nature Clinical Practice.

Author information

Author notes

  1. 601 North Caroline Street, Suite 5073A, Johns Hopkins Outpatient Center, Baltimore, MD 21093, USA rwityk@jhmi.edu

Authors and Affiliations

  1. RJ Wityk is Associate Professor of Neurology and Medicine at Johns Hopkins University School of Medicine, Baltimore, MD, USA.,

    Robert J Wityk

Authors
  1. Robert J Wityk
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wityk, R. Tissue plasminogen activator for acute ischemic stroke—is it for the elderly?. Nat Rev Neurol 4, 416–417 (2008). https://doi.org/10.1038/ncpneuro0835

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpneuro0835

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing