The technologies of structural and functional genomics promise to accelerate the pace of discovery in biology. In the pharmaceutical industry, these technologies have led to the identification of new drug targets and new drugs. In agriculture, these technologies should also have a dramatic impact on accelerating the pace of discovery. In particular, it should be reasonably straightforward to apply these technologies to small molecule discovery by identifying new, validated targets for herbicides. The approach I will discuss utilizes high-throughput DNA sequencing, high-throughput reverse genetics and knowledge-based computer systems to identify new targets for crop protection chemical discovery.