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Common features between chromaffin and neural progenitor cells

Molecular Psychiatry volume 17, page 351 (2012)Cite this article

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The image depicts putative progenitor cells in the adult rodent adrenal medulla and brain. In the left panel (‘Adrenal’), the adrenal medulla is distinguished by immunofluorescent staining against tyrosine hydroxylase (red). A non-stained area of the image corresponding to adrenal cortical tissue can be seen in the lower left corner. Within the adrenal medulla, cells expressing the green fluorescence protein (GFP) can be detected. In the transgenic nestin–GFP mice used for this image, GFP expression is driven by regulatory elements of the nestin gene, a gene which is highly expressed in neural precursors and neural stem cells in the developing and adult mammalian central nervous system. Nestin–GFP transgenic mice were kindly provided by Grigori Enikolopov, Cold Spring Harbor Laboratory, NY, USA.1 In the right panel (‘Brain’), the image is from the adult rat subventricular zone lining a lateral ventricle. Blood vessels are distinguished by immunofluorescence labeling for the antigen RECA-1. Putative neural precursor cells are seen in green, following immunofluorescence labeling with an antibody against the basic helix-loop-helix transcription factor Hes3. The large number of Hes3+ cells is a result of pharmacological targeting of these cells 5 days before tissue collection.2 For more information on this topic, please refer to the article by Bornstein et al., on pages 354–358.

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References

  1. Mignone JL, Kukekov V, Chiang AS, Steindler D, Enikolopov G . Neural stem and progenitor cells in nestin-GFP transgenic mice. J Comp Neurol 2004; 469: 311–324.

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  2. Androutsellis-Theotokis A, Rueger MA, Park DM, Mkhikian H, Korb E, Poser SW et al. Targeting neural precursors in the adult brain rescues injured dopamine neurons. Proc Natl Acad Sci USA 2009; 106: 13570–13575.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, University of Dresden, Dresden, Germany

    A Androutsellis-Theotokis, M F Rubin de Celis, M Ehrhart-Bornstein & S R Bornstein

  2. Center for Regenerative Therapies Dresden, Dresden, Germany

    A Androutsellis-Theotokis, M Ehrhart-Bornstein & S R Bornstein

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  1. A Androutsellis-Theotokis
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  2. M F Rubin de Celis
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  3. M Ehrhart-Bornstein
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  4. S R Bornstein
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Androutsellis-Theotokis, A., Rubin de Celis, M., Ehrhart-Bornstein, M. et al. Common features between chromaffin and neural progenitor cells. Mol Psychiatry 17, 351 (2012). https://doi.org/10.1038/mp.2012.18

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