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A golden retriever with bilateral blepharospasm and ocular discharge

Lab Animal volume 43, pages 127–130 (2014)Cite this article

A small colony of dogs with a golden retriever background was established at the University of Pennsylvania. The colony consisted of 15 dogs affected with golden retriever muscular dystrophy (GRMD)1 as well as normal, non-affected dogs enrolled in a gene therapy study for the development of a treatment for human Duchenne muscular dystrophy. All dogs were housed indoors in kennels with raised floors and had access to food and water ad libitum. The health of the dogs was monitored daily by husbandry, veterinary and research staff.

The protocol for this study was approved by the University of Pennsylvania IACUC in accordance with the Guide for the Care and Use of Laboratory Animals2 and the Animal Welfare Act3. All research activities were done in a facility accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC).

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Figure 1: Ocular discharge originating from medial canthus in the left eye.
Figure 2: The left eye after shaving for surgical preparation.
Figure 3: Illustrations of the left eye during corrective surgery.
Figure 4: The left eye 6 d after corrective surgery.
Figure 5

References

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Acknowledgements

We thank the members of the laboratory of Dr. Hansell Stedman for their collaboration on this case and Ms. Mary Leonard for the illustration.

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Authors and Affiliations

  1. University of Pennsylvania, University Laboratory Animal Resources, Philadelphia, PA

    Travis M. Hagedorn &  JanLee A. Jensen

  2. University of Kansas Medical Center, Laboratory Animal Resources, Kansas City, KS

    Travis M. Hagedorn

  3. Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA

    András M. Komáromy

  4. Department of Small Animal Clinical Sciences, Michigan State University, College of Veterinary Medicine, East Lansing, MI

    András M. Komáromy

Authors
  1. Travis M. Hagedorn
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  2. JanLee A. Jensen
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  3. András M. Komáromy
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Correspondence to Travis M. Hagedorn.

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Hagedorn, T., Jensen, J. & Komáromy, A. A golden retriever with bilateral blepharospasm and ocular discharge. Lab Anim 43, 127–130 (2014). https://doi.org/10.1038/laban.329

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