This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Masuo K . Roles of beta2- and beta3-adrenoceptor polymorphisms in hypertension and metabolic syndrome. Int J Hypertens 2010; 2010: 832821.
Kou R, Michel T . Epinephrine regulation of the endothelial nitric-oxide synthase: roles of RAC1 and beta3-adrenergic receptors in endothelial NO signaling. J Biol Chem 2007; 282 (45): 32719–32729.
Dessy C, Moniotte S, Ghisdal P, Havaux X, Noirhomme P, Balligand JL . Endothelial beta3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarization. Circulation 2004; 110 (8): 948–954.
Trombetta IC, Batalha LT, Rondon MU, Laterza MC, Frazzatto E, Alves MJ et al. Gly16+Glu27 {beta}2-adrenoceptor polymorphisms cause increased forearm blood flow responses to mental stress and handgrip in humans. J Appl Physiol 2005; 98 (3): 787–794.
Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S et al. Time of onset of non insuline dependent diabetes mellitus and genetic variation in the β3-adrenergic receptor gene. N Engl J Med 1995; 333 (6): 343–347.
De Luis DA, Ballesteros M, Ruiz E, Muñoz C, Penacho A, Iglesias P et al. Polymorphism Trp64Arg of beta 3 adrenoreceptor gene: allelic frequencies and influence on insulin resistance in a multicenter study of Castilla-León. Nutr Hosp 2010; 25 (2): 299–303.
Festa A, Krugluger W, Shnawa N, Hopmeier P, Haffner SM, Schernthaner G . Trp64Arg polymorphism of the beta3-adrenergic receptor gene in pregnancy: association with mild gestational diabetes mellitus. J Clin Endocrinol Metab 1999; 84 (5): 1695–1699.
Mitchell BD, Blangero J, Comuzzie AG, Almasy LA, Shuldiner AR, Silver K et al. A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans. J Clin Invest 1998; 101 (3): 584–587.
Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE . Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 1994; 24 (6): 1468–1474.
López-Bermejo A, Chico-Julià B, Castro A, Recasens M, Esteve E, Biarnés J et al. Alpha defensins 1, 2, and 3: potential roles in dyslipidemia and vascular dysfunction in humans. Arterioscler Thromb Vasc Biol 2007; 27 (5): 1166–1171.
Matsuda K, Teregawa H, Fukuda Y, Ueda K, Higashi Y, Sakai K et al. Response of the left anterior descending coronary artery to acetylcholine in patients with chest pain and angiographically normal coronary arteries. Am J Cardiol 2003; 92 (12): 1394–1398.
Boyle JJ . Vascular smooth muscle cell apoptosis in atherosclerosis. Int J Exp Pathol 1999; 80 (4): 197–203.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies this paper on the Journal of Human Hypertension website
Supplementary information
Rights and permissions
About this article
Cite this article
Xifra, G., Castro, A., Ortega, F. et al. The Trp64Arg β3-adrenergic receptor gene polymorphism is associated with endothelium-dependent vasodilatation. J Hum Hypertens 29, 134–135 (2015). https://doi.org/10.1038/jhh.2014.17
Published:
Issue Date:
DOI: https://doi.org/10.1038/jhh.2014.17