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First-line extracorporeal photochemotherapy for acute GVHD after unmanipulated haploidentical BMT following nonmyeloablative conditioning and post transplantation CY

Bone Marrow Transplantation volume 49, pages 317–318 (2014)Cite this article

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AlloASCT is considered the standard treatment for many hematological malignanices. The availability of a donor is of concern considering that almost half of Caucasian patients have a HLA-identical sibling or matched unrelated donor. Alternative nonidentical donors such as cord blood or haploidentical-related donors could expand the accessibility of alloSCT for all patients. Recently, encouraging results have been obtained using haploidentical-related donor, nonmyeloblative (NMA) regimens, T-replete BM and post-transplantation CY.1 High dose, post-transplantation CY administered at fixed time after BM infusion, is supposed to kill alloreactive donor and host T cells, activated by respective antigens, thus reducing the incidence of GVHD and host vs graft reaction.2

In order to reduce the incidence of infections and relapse incidence in high-risk patients, we decide to treat patients with acute GVHD (aGVHD) by extracorporeal photochemotherapy (ECP) as first-line therapy avoiding long-term steroid administration.

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Authors and Affiliations

  1. Humanitas Cancer Center, Bone Marrow Transplantation Unit, Istituto Clinico Humanitas, Rozzano, Italy

    L Castagna, L Morabito, E Mauro, S Bramanti, B Sarina, L Giordano, R Crocchiolo & A Santoro

  2. Immunohematology and Transfusion Service and Apheresis and Cell Therapy Unit, Fondazione IRCCS Policlinico S Matteo (Pavia), Pavia, Italy

    C Perotti

Authors
  1. L Castagna
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  2. L Morabito
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  3. E Mauro
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  4. C Perotti
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  5. S Bramanti
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  6. B Sarina
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  7. L Giordano
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  8. R Crocchiolo
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  9. A Santoro
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Correspondence to L Castagna.

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Castagna, L., Morabito, L., Mauro, E. et al. First-line extracorporeal photochemotherapy for acute GVHD after unmanipulated haploidentical BMT following nonmyeloablative conditioning and post transplantation CY. Bone Marrow Transplant 49, 317–318 (2014). https://doi.org/10.1038/bmt.2013.174

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  • DOI: https://doi.org/10.1038/bmt.2013.174

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