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Mycobacterium tuberculosis infection: a rare late complication after cord blood hematopoietic SCT

Bone Marrow Transplantation volume 43, pages 667–668 (2009)Cite this article

The use of cord blood units (CBU) as a source of hematopoietic stem cells (HSC) for transplant has increased during the last few years.1 The main obstacle for the use of CB for adult transplantation is the proportionally small content of HSC, which leads to delayed engraftment, relatively slower immunological recovery and higher incidence of graft failure when compared with other HSC sources. The end result is a higher incidence of TRM secondary to infections.1, 2

Mycobacterial tuberculosis (MT) infections are rare among hematopoietic SCT (HSCT) patients, but are more likely to affect patients from countries with high incidence and prevalence of tuberculosis.3, 4, 5, 6, 7 Here, we discuss a case of MT in a CB transplant recipient coming from an MT endemic area, and who received his transplant in the United States.

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Authors and Affiliations

  1. Bone Marrow Transplantation Division, Albert Einstein Hospital, São Paulo, Brazil

    R A De Assis, F R Kerbauy, M Rodrigues, F S Seguro, L F C Aranha & N Hamerschlak

  2. Department of Lymphoma, M.D. Anderson Cancer Center, Houston, TX, USA

    L Fayad

  3. Department of Stem Cell Transplantation and Cell Therapy, M.D. Anderson Cancer Center, Houston, TX, USA

    E J Shpall & M de Lima

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  1. R A De Assis
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  2. F R Kerbauy
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  3. M Rodrigues
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  4. F S Seguro
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  5. L F C Aranha
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  6. L Fayad
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  7. E J Shpall
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  8. M de Lima
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  9. N Hamerschlak
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Correspondence to N Hamerschlak.

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De Assis, R., Kerbauy, F., Rodrigues, M. et al. Mycobacterium tuberculosis infection: a rare late complication after cord blood hematopoietic SCT. Bone Marrow Transplant 43, 667–668 (2009). https://doi.org/10.1038/bmt.2008.379

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