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Myosin steps backwards

All myosin motors move in the same direction — or so it was thought. The discovery of one form that acts in reverse sheds new light on the mechanics of these molecular motors.

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Figure 1: Space-filling model of myosin subfragment 1, indicating the position of the converter region (grey) at the base of the α-helical lever arm15.
Figure 2: Simple mechanical model for myosin motors with opposite polarity of force generation.

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Correspondence to Manfred Schliwa.

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Schliwa, M. Myosin steps backwards. Nature 401, 431–432 (1999). https://doi.org/10.1038/46692

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