Abstract
Yoo and Lubec show that the amount of p25 is decreased in the brains they studied from patients with Alzheimer's disease or Down's syndrome. Their results persuaded us to conduct a more extensive survey of the p25/p35 ratio in AD brains (to be published elsewhere), as the number of samples was small in both of our studies (eight AD brains in our original study and six in theirs). After analysing a further 25 AD brains and those from 25 age-matched controls, we found that p25 levels are consistently higher in AD brains and that the difference is statistically significant (Student's t-test). This is in agreement with our original observations1, as well as being consistent with earlier reports of increased Cdk5 kinase activity in AD brain2 and of increased amounts of p25 in an animal model of neurodegeneration3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Patrick, G. N. et al. Nature 402, 615–622 (1999).
Lee, K. Y. et al. Neurosci. Res. 34, 21–29 (1999).
Nguyen, M. D., Lariviere, R. C. & Julien, J.-P. Neuron 30, 135–147 (2001).
Grynspan, R., Griffin, W. R., Cataldo, A., Katayama, S. & Nixon, R. Brain Res. 763, 145–158 (1997).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Patrick, G., Zukerberg, L., Nikolic, M. et al. p25 protein in neurodegeneration. Nature 411, 764–765 (2001). https://doi.org/10.1038/35081149
Issue Date:
DOI: https://doi.org/10.1038/35081149
This article is cited by
-
PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation
Journal of Neural Transmission (2009)
-
p53, Apaf-1, caspase-3, and -9 are dispensable for Cdk5 activation during cell death
Cell Death & Differentiation (2006)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
