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An approach for the synthesis of E- and Z- trisubstituted alkenes in high stereoisomeric purity is developed by merging catalytic cross-metathesis and cross-coupling processes.
Modelling the reactions of water with the crusts of early Earth and Mars sheds light on how water was transported through their crusts to give the surfaces we see today.
Interferometric images of the surface of the giant star π1 Gruis reveal few but large convective cells, consistent with existing models of stellar surface convection.
The observed electromagnetic emission from GW170817 suggests that a ‘cocoon’ of mildly relativistic material was released as a jet transferred its energy to the neutron-rich dynamical ejecta from the merger.
Cellular senescence induced by chemotherapy leads to the acquisition of stemness in cancer cells, which results in enhanced tumour-promoting capacity after forced release or spontaneous escape from the senescent cell-cycle arrest.
Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.
Analyses of potential and actual biomass stocks indicate that trade-offs exist between conserving carbon stocks on managed land and raising the contribution of biomass to raw material and energy supply for the mitigation of climate change.
CRISPR–Cas9 genome editing is used to correct a dominant-negative mutation in a mouse model of inherited deafness, resulting in improvements in cochlear function and hearing.
The cryo-electron microscopy structure of full-length mouse Piezo1 reveals six Piezo repeats, and 26 transmembrane helices per protomer, and shows that a kinked helical beam and anchor domain link the Piezo repeats to the pore and control gating allosterically.
Statistical modelling of global survey datasets of waterbirds as an indicator taxon for biodiversity changes in wetland ecosystems demonstrates that effective governance is the strongest predictor of species abundance increases and conservation benefits.
The cryo-electron microscopy structure of the calcium channel TRPV6 in its open and closed states demonstrates a novel gating mechanism involving an alanine hinge.
Application of an electric field changes the transport and optical properties of samarium nickelate submerged in water, making it a suitable passive sensor of weak electric fields in salt water.
Mapping the three-dimensional trajectory of a Neptune-mass exoplanet across the disk of its cool star reveals that its orbit is nearly perpendicular to the stellar equator, implying the existence of a yet-undetected outer companion planet.
A weak magnetic field regulates magnetically gated accretion of gas from a companion star onto the white dwarf in the binary system MV Lyrae, previously labelled as a ‘non-magnetic’ system.
Geophysical and geological data reveal increased ice-sheet variability and surface meltwater—possibly analogous to future conditions—offshore of the Aurora subglacial basin of East Antarctica during warm climate intervals of the past 50 million years.
Measurements of the composition-dependent viscosity of rhyolitic magma reveal a tipping point that changes the physical properties of the melt and controls the transition between effusive and explosive eruptions.
Electrons derived from cosmic rays become trapped in the radiation belts that surround Earth, but how the electrons are generated has been uncertain; new measurements confirm the involvement of neutron decay.
In vivo deuterium labelling reveals a quiescent population of long-lived human virus-specific memory CD8 T cells that maintain the epigenetic landscape of effector cells, which facilitates rapid responses to pathogen re-exposure.