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| Open AccessCatalytic DxD motif caged in Asx-turn and Met–aromatic interaction attenuates the pathogenic glycosylation of SseK2/NleB2 effectors
- Eunhee Koh
- , Uijin Kim
- & Hyun-Soo Cho
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| Open AccessLow-resolution description of the conformational space for intrinsically disordered proteins
- Daniel Förster
- , Jérôme Idier
- & Thérèse E. Malliavin
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| Open AccessCondensed tannins act as anthelmintics by increasing the rigidity of the nematode cuticle
- Luise Greiffer
- , Eva Liebau
- & Verena Spiegler
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| Open AccessEffects of cancer-associated point mutations on the structure, function, and stability of isocitrate dehydrogenase 2
- Xiang Chen
- , Peipei Yang
- & Wen-Bin Ou
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| Open AccessDiscovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays
- Olivier A. Pierrat
- , Manjuan Liu
- & Rob L. M. van Montfort
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| Open AccessParallel functional annotation of cancer-associated missense mutations in histone methyltransferases
- Ashley J. Canning
- , Susan Viggiano
- & Michael S. Cosgrove
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| Open AccessDiscovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor
- Gustavo Fernando Mercaldi
- , Eduardo Henrique Salviano Bezerra
- & Daniela Barretto Barbosa Trivella
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| Open AccessStructure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM
- Jean-Marc Jeckelmann
- , Thomas Lemmin
- & Dimitrios Fotiadis
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| Open AccessIn vitro and in vivo assessment of the antioxidant potential of isoxazole derivatives
- Mohammed Hawash
- , Nidal Jaradat
- & Ahmed Mousa
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| Open AccessMouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles
- Michiru Otaki
- , Nozomi Hirane
- & Shin-Ichiro Nishimura
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| Open AccessExploring the In situ pairing of human galectins toward synthetic O-mannosylated core M1 glycopeptides of α-dystroglycan
- Lareno L. Villones Jr.
- , Anna-Kristin Ludwig
- & Hiroshi Hinou
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| Open AccessMechanical properties, degree of sclerotisation and elemental composition of the gastric mill in the red swamp crayfish Procambarus clarkii (Decapoda, Crustacea)
- Wencke Krings
- , Jan-Ole Brütt
- & Stanislav N. Gorb
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| Open AccessMapping periplasmic binding protein oligosaccharide recognition with neutron crystallography
- Shantanu Shukla
- , Dean A. Myles
- & Matthew J. Cuneo
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| Open AccessStructure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules
- Hideharu Hashimoto
- , Daniel H. Ramirez
- & Erik W. Debler
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| Open AccessThe iron-sulfur cluster is essential for DNA binding by human DNA polymerase ε
- Alisa E. Lisova
- , Andrey G. Baranovskiy
- & Tahir H. Tahirov
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| Open AccessLoss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N-terminal domain hydrophobic core
- Juan Luis Pacheco-García
- , Dmitry S. Loginov
- & Angel L. Pey
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| Open AccessStructural studies of the phosphoribosyltransferase involved in cobamide biosynthesis in methanogenic archaea and cyanobacteria
- Victoria L. Jeter
- , Anne H. Schwarzwalder
- & Jorge C. Escalante-Semerena
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| Open AccessProtein delivery to living cells by thermal stimulation for biophysical investigation
- Francesco Torricella
- , Letizia Barbieri
- & Lucia Banci
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| Open AccessA new obligate CXCL4–CXCL12 heterodimer for studying chemokine heterodimer activities and mechanisms
- Khanh T.P. Nguyen
- , Brian Volkman
- & Irina V. Nesmelova
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| Open AccessDesign, synthesis and computational study of new benzofuran hybrids as dual PI3K/VEGFR2 inhibitors targeting cancer
- Omar A. El-Khouly
- , Morkos A. Henen
- & Shahenda M. El-Messery
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| Open AccessRetrospective study for the universal applicability of the residue-based linear free energy relationship in the two-state exchange of protein molecules
- Daisuke Fujinami
- , Seiichiro Hayashi
- & Daisuke Kohda
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| Open AccessCell-free protein crystallization for nanocrystal structure determination
- Satoshi Abe
- , Junko Tanaka
- & Takafumi Ueno
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| Open AccessCrystal structures of FNIP/FGxxFN motif-containing leucine-rich repeat proteins
- Trevor Huyton
- , Mamta Jaiswal
- & Dirk Görlich
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| Open AccessUnravelling the role of transient redox partner complexes in P450 electron transfer mechanics
- Tatiana Y. Hargrove
- , David C. Lamb
- & Galina I. Lepesheva
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| Open AccessTargeting and ultrabroad insight into molecular basis of Resistance-nodulation-cell division efflux pumps
- Hooria Seyedhosseini Ghaheh
- , Mohammad Sadegh Damavandi
- & Seyed Hossein Hejazi
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| Open AccessConfrontation of AlphaFold models with experimental structures enlightens conformational dynamics supporting CYP102A1 functions
- Philippe Urban
- & Denis Pompon
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| Open AccessIdentification of potential modulators of IFITM3 by in-silico modeling and virtual screening
- Vikas Tiwari
- & Shruthi Viswanath
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| Open AccessComplete chloroplast genome structure of four Ulmus species and Hemiptelea davidii and comparative analysis within Ulmaceae species
- Yichao Liu
- , Yongtan Li
- & Minsheng Yang
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| Open AccessActin cable formation and epidermis–dermis positional relationship during complete skin regeneration
- Kento Takaya
- , Keisuke Okabe
- & Kazuo Kishi
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| Open AccessIntegrated analysis to study the interplay between post-translational modifications (PTM) in hepatitis C virus proteins and hepatocellular carcinoma (HCC) development
- Aqsa Ikram
- , Bisma Rauff
- & Hussnain Ahmed Janjua
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| Open AccessMolecular insights on ar-turmerone as a structural, functional and pharmacophoric analogue of synthetic mosquito repellent DEET by comprehensive computational assessment
- Priyashi Rao
- , Dweipayan Goswami
- & Rakesh M. Rawal
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| Open AccessDisarming of type I-F CRISPR-Cas surveillance complex by anti-CRISPR proteins AcrIF6 and AcrIF9
- Egle Kupcinskaite
- , Marijonas Tutkus
- & Tomas Sinkunas
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| Open AccessIce thickness monitoring for cryo-EM grids by interferometry imaging
- Markus Matthias Hohle
- , Katja Lammens
- & Christophe Jung
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| Open AccessCharacterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling
- Marius Kausas
- , Diego Esposito
- & Franca Fraternali
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| Open AccessIdentification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR)
- Elena Erausquin
- , María Morán-Garrido
- & Jacinto López-Sagaseta
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| Open AccessA pocket-based 3D molecule generative model fueled by experimental electron density
- Lvwei Wang
- , Rong Bai
- & Bo Huang
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| Open AccessIn silico analyses of Wnt1 nsSNPs reveal structurally destabilizing variants, altered interactions with Frizzled receptors and its deregulation in tumorigenesis
- Amalesh Mondal
- , Debarati Paul
- & Achintya Mohan Goswami
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| Open AccessDynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1)
- Urvashi Sharma
- , Sandrine Vadon-Le Goff
- & Nushin Aghajari
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| Open AccessPrediction of the structural interface between fibroblast growth factor23 and Burosumab using alanine scanning and molecular docking
- Karnpob Kanhasut
- , Kannan Tharakaraman
- & Ram Sasisekharan
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| Open AccessIdentification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site
- Eric R. Goedken
- , Maria A. Argiriadi
- & Chaohong Sun
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| Open AccessStructural bioinformatics analysis of SARS-CoV-2 variants reveals higher hACE2 receptor binding affinity for Omicron B.1.1.529 spike RBD compared to wild type reference
- Vedat Durmaz
- , Katharina Köchl
- & Christian C. Gruber
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| Open AccessBiophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects
- Mohanraj Gopalswamy
- , Tobias Kroeger
- & Holger Gohlke
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| Open AccessLow pH structure of heliorhodopsin reveals chloride binding site and intramolecular signaling pathway
- Jessica E. Besaw
- , Jörg Reichenwallner
- & Oliver P. Ernst
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| Open AccessStructural characterization of aspartate-semialdehyde dehydrogenase from Pseudomonas aeruginosa and Neisseria gonorrhoeae
- S. L. Teakel
- , J. W. Fairman
- & J. K. Forwood
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| Open AccessS-Pred: protein structural property prediction using MSA transformer
- Yiyu Hong
- , Jinung Song
- & Woong-Hee Shin
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| Open AccessNovel detection of stem cell niche within the stroma of limbus in the rabbit during postnatal development
- Nada Abdellah
- & Sara M. M. El- Desoky
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| Open AccessEfflux dynamics of the antiseizure drug, levetiracetam, through the P-glycoprotein channel revealed by advanced comparative molecular simulations
- Esmaeil Behmard
- , Ebrahim Barzegari
- & Ali A. Asadi-Pooya
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| Open AccessDimerization processes for light-regulated transcription factor Photozipper visualized by high-speed atomic force microscopy
- Akihiro Tsuji
- , Hayato Yamashita
- & Masayuki Abe
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| Open AccessMetal deposition and shape reproduction at biological temperatures on cell-level samples
- Kenshin Takemura
- , Taisei Motomura
- & Naoki Matsuda