Fat metabolism articles within Nature

Featured

  • Article
    | Open Access

    Mitochondria have a pivotal role in the transport of dietary lipids in enterocytes, a finding that might have relevance to understanding the aberrant gastrointestinal function in patients with mitochondrial disorders.

    • Chrysanthi Moschandrea
    • , Vangelis Kondylis
    •  & Manolis Pasparakis

  • Article
    | Open Access

    GDF15 treatment in mice counteracts compensatory reductions in energy expenditure, resulting in greater weight loss and reductions in non-alcoholic fatty liver disease compared to caloric restriction alone.

    • Dongdong Wang
    • , Logan K. Townsend
    •  & Gregory R. Steinberg

  • Article |

    An adipocyte-selective product of the Clstn3 locus (CLSTN3β) facilitates the use of stored triglyceride by limiting lipid droplet (LD) expansion, defining a molecular mechanism that regulates LD form and function to facilitate lipid utilization in thermogenic adipocytes.

    • Kevin Qian
    • , Marcus J. Tol
    •  & Peter Tontonoz

  • Article
    | Open Access

    Untargeted metabolomics demonstrate that apoptotic brown adipocytes release a specific pattern of metabolites with purine metabolites being highly enriched, and inosine is identified as a metabolite released during apoptosis regulating thermogenic fat and counteracting obesity.

    • Birte Niemann
    • , Saskia Haufs-Brusberg
    •  & Alexander Pfeifer

  • Article |

    A single-cell atlas of white adipose tissue from mouse and human reveals diverse cell types and similarities and differences across species and dietary conditions.

    • Margo P. Emont
    • , Christopher Jacobs
    •  & Evan D. Rosen

  • Article |

    A genetic mouse model is used to reveal a two-pronged mechanism of fructose-induced de novo lipogenesis in the liver, in which fructose catabolism in hepatocytes provides a signal to promote lipogenesis, whereas fructose metabolism by the gut microbiota provides acetate as a substrate to feed lipogenesis.

    • Steven Zhao
    • , Cholsoon Jang
    •  & Kathryn E. Wellen

  • Article |

    A role and mechanism of action are identified for INSP3R1 in the stimulation of hepatic gluconeogenesis and mitochondrial oxidation by glucagon, suggesting that INSP3R1 may be a target for ameliorating dysregulation of hepatic glucose metabolism.

    • Rachel J. Perry
    • , Dongyan Zhang
    •  & Gerald I. Shulman

  • Letter |

    Cold exposure activates brown adipose tissue (BAT) through the sympathetic nervous system, and previous studies have reported inhibitory effects of the purinergic transmitter adenosine in BAT from hamster or rat; here adenosine/A2A signalling is shown to be involved in sympathetic activation of human and murine brown adipocytes to allow protection of mice from diet-induced obesity.

    • Thorsten Gnad
    • , Saskia Scheibler
    •  & Alexander Pfeifer

  • Outlook |

    For children with epilepsy whose condition is resistant to medication, a high-fat, low-carbohydrate diet may help bring their seizures under control.

    • Rachel Brazil

  • Letter |

    Nicotinamide N-methyltransferase (NNMT) expression is increased in white adipose tissue and liver of obese and diabetic mice, Nnmt knockdown protects against diet-induced obesity by altering the availability of adipose S-adenosylmethionine and NAD+, rendering Nnmt a novel target for treating obesity and type 2 diabetes.

    • Daniel Kraus
    • , Qin Yang
    •  & Barbara B. Kahn

  • Letter |

    Gene-expression studies are used to elucidate the relationship between cholesterol regulation and angiogenesis: apolipoprotein A-1 binding protein (AIBP) is found to enhance cholesterol influx from endothelial cells to high-density lipoprotein, and the resulting cholesterol depletion alters membrane lipid order in the vasculature, leading to decreased vascular endothelial growth factor receptor signalling.

    • Longhou Fang
    • , Soo-Ho Choi
    •  & Yury I. Miller

  • Article |

    A non-coding polymorphism at a locus associated with myocardial infarction in humans creates a CCAAT/enhancer binding protein transcription factor binding site and alters the hepatic expression of the SORT1 gene. These authors show that modulating Sort1 levels in mouse liver alters levels of plasma low-density lipoprotein cholesterol and very low-density lipoprotein, potentially explaining why polymorphisms at this locus are associated with heart disease.

    • Kiran Musunuru
    • , Alanna Strong
    •  & Daniel J. Rader

  • Article |

    Lipid concentration in the serum is one of the most important risk factors for coronary artery disease and can be targeted for therapeutic intervention. A genome-wide association study in >100,000 individuals of European ancestry now finds 95 significantly associated loci that also affect lipid traits in non-European populations. Among associated loci are those involved in cholesterol metabolism, known targets of cholesterol-lowering drugs and those that contribute to normal variation in lipid traits and to extreme lipid phenotypes.

    • Tanya M. Teslovich
    • , Kiran Musunuru
    •  & Sekar Kathiresan

  • News & Views |

    Although sphingolipids are vital cellular components, the path to their production is paved with toxic intermediates. Orm proteins allow cells to form these lipids without killing themselves in the process.

    • Fikadu G. Tafesse
    •  & Joost C. M. Holthuis

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