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| Open AccessMultifunctional Core/Shell Nanoparticles Cross-linked Polyetherimide-folic Acid as Efficient Notch-1 siRNA Carrier for Targeted Killing of Breast Cancer
- Hong Yang
- , Ying Li
- & Yiyao Liu
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| Open AccessMolecular Characterization of the Monoclonal Antibodies Composing ZMAb: A Protective Cocktail Against Ebola Virus
- Jonathan Audet
- , Gary Wong
- & Xiangguo Qiu
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| Open AccessDampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices
- Maurizio Pezzoli
- , Abdeladim Elhamdani
- & Henry Markram
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| Open AccessAntitumor effects and molecular mechanisms of figitumumab, a humanized monoclonal antibody to IGF-1 receptor, in esophageal carcinoma
- Tiehong Zhang
- , Hongchang Shen
- & Jiajun Du
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| Open AccessUrinary metabolic profiling of rat models revealed protective function of scoparone against alcohol induced hepatotoxicity
- Aihua Zhang
- , Hui Sun
- & Xijun Wang
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| Open AccessIncreased N-glycosylation of Asn88 in serum pancreatic ribonuclease 1 is a novel diagnostic marker for pancreatic cancer
- Daisuke Nakata
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| Open AccessDiscriminative stimulus effects of the novel imidazoline I2 receptor ligand CR4056 in rats
- Yanyan Qiu
- , Xiao-Hua He
- & Jun-Xu Li
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| Open AccessReduction of intraarticular adhesion by topical application of colchicine following knee surgery in rabbits
- Yu Sun
- , Yuan Liang
- & Lianqi Yan
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| Open AccessA gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine
- Kuen-Haur Lee
- , Hsiang-Ling Lo
- & Pei-Ming Yang
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| Open AccessNotoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation
- Shijun Yan
- , Zhi Li
- & Wensheng Zhang
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| Open AccessA crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologs
- Tian Liu
- , Peng Guo
- & Qing Yang
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| Open AccessNovel VCP modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa
- Hanako Ohashi Ikeda
- , Norio Sasaoka
- & Akira Kakizuka
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| Open AccessCalpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes
- Yoko Nabeshima
- , Miwa Washida
- & Yo-ichi Nabeshima
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| Open AccessProtective Effect of Aframomum melegueta phenolics Against CCl4-Induced Rat Hepatocytes Damage; Role of Apoptosis and Pro-inflammatory Cytokines inhibition
- Ali M. El-Halawany
- , Riham Salah El Dine
- & Masao Hattori
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| Open AccessA tool kit for rapid cloning and expression of recombinant antibodies
- Tihomir S. Dodev
- , Panagiotis Karagiannis
- & Andrew J. Beavil
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| Open AccessCytological and Subcellular Response of Cells Exposed to the Type-1 RIP Curcin and its Hemocompatibility Analysis
- M. Sheikh Mohamed
- , Srivani Veeranarayanan
- & D. Sakthi Kumar
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| Open AccessLiquiritigenin alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model
- Li Chen
- , Wei Chen
- & Naijun Zhu
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| Open AccessRational design and validation of a Tip60 histone acetyltransferase inhibitor
- Chunxia Gao
- , Emer Bourke
- & James A. L. Brown
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| Open AccessA method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans
- Pénélope A. Andreux
- , Laurent Mouchiroud
- & Johan Auwerx
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| Open AccessExpression of human solute carrier family transporters in skin: possible contributor to drug-induced skin disorders
- Ryoichi Fujiwara
- , Saya Takenaka
- & Tomoo Itoh
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| Open AccessSynergism and Rules of the new Combination drug Yiqijiedu Formulae (YQJD) on Ischemic Stroke based on amino acids (AAs) metabolism
- Jian Gao
- , Chang Chen
- & Shao-Jing Li
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| Open AccessSynergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis
- Jichuang Wang
- , Zhou Jiang
- & Lee Jia
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| Open AccessUSP8 modulates ubiquitination of LRIG1 for Met degradation
- Young Mi Oh
- , Saet Byoul Lee
- & Kyung-Ah Kim
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| Open AccessAntinociceptive effects of curcumin in a rat model of postoperative pain
- Qing Zhu
- , Yuehua Sun
- & Jun-Xu Li
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| Open AccessBerberine exposure triggers developmental effects on planarian regeneration
- Linda Balestrini
- , Maria Emilia Isolani
- & Renata Batistoni
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| Open AccessLipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes
- Lin Ding
- , Jun-Lin Liu
- & Jing Shang
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| Open Access2′-Epi-uscharin from the Latex of Calotropis gigantea with HIF-1 Inhibitory Activity
- Supawadee Parhira
- , Guo-Yuan Zhu
- & Zhi-Hong Jiang
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| Open AccessApoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma
- Simona Daniele
- , Sabrina Taliani
- & Claudia Martini
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| Open AccessReductive Methylation and Mutation of an Anthrax Toxin Fusion Protein Modulates its Stability and Cytotoxicity
- Christopher Bachran
- , Pradeep K. Gupta
- & Stephen H. Leppla
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| Open AccessOn-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip
- Tomoyuki Kaneko
- , Fumimasa Nomura
- & Kenji Yasuda
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| Open AccessChemical Modulation of the Biological Activity of Reutericyclin: a Membrane-Active Antibiotic from Lactobacillusreuteri
- Philip T. Cherian
- , Xiaoqian Wu
- & Julian G. Hurdle
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| Open AccessNitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development
- Carolina B. Moraes
- , Miriam A. Giardini
- & Lucio H. Freitas-Junior
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| Open AccessThe Acyclic Retinoid Peretinoin Inhibits Hepatitis C Virus Replication and Infectious Virus Release in Vitro
- Tetsuro Shimakami
- , Masao Honda
- & Shuichi Kaneko
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| Open AccessDesigning of promiscuous inhibitors against pancreatic cancer cell lines
- Rahul Kumar
- , Kumardeep Chaudhary
- & Gajendra P. S. Raghava
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| Open AccessThe optimal concentration of topical hydroxycamptothecin in preventing intraarticular scar adhesion
- Yuan Liang
- , Yu Sun
- & Jinshan He
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| Open AccessPharmacological targeting of the β-amyloid precursor protein intracellular domain
- Caterina Branca
- , Ilenia Sarnico
- & Marina Pizzi
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| Open AccessAntidepressant-like effects of auraptenol in mice
- Xiaosu Gu
- , Yong Zhou
- & Kaifu Ke
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| Open AccessSoybean greatly reduces valproic acid plasma concentrations: A food–drug interaction study
- Anu Marahatta
- , Bidur Bhandary
- & Han-Jung Chae
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| Open AccessNitric Oxide Inhibits Hetero-adhesion of Cancer Cells to Endothelial Cells: Restraining Circulating Tumor Cells from Initiating Metastatic Cascade
- Yusheng Lu
- , Ting Yu
- & Lee Jia
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| Open AccessTargeting Extracellular DNA to Deliver IGF-1 to the Injured Heart
- Raffay S. Khan
- , Mario D. Martinez
- & Michael E. Davis
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| Open AccessThe Effect of microRNAs in the Regulation of Human CYP3A4: a Systematic Study using a Mathematical Model
- Zhiyun Wei
- , Songshan Jiang
- & Qinghe Xing
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| Open AccessHigh-throughput de novo screening of receptor agonists with an automated single-cell analysis and isolation system
- Nobuo Yoshimoto
- , Kenji Tatematsu
- & Shun'ichi Kuroda
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| Open AccessDrug Delivery by Tattooing to Treat Cutaneous Leishmaniasis
- Marina Temi Shio
- , Marilene Paquet
- & Anny Fortin
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| Open AccessBreast tumor subgroups reveal diverse clinical prognostic power
- Zhaoqi Liu
- , Xiang-Sun Zhang
- & Shihua Zhang
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| Open AccessScreening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells
- Vehary Sakanyan
- , Marie Angelini
- & Fabrice Fleury
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| Open AccessReconstitution of coronary vasculature by an active fraction of Geum japonicum in ischemic hearts
- Hao Chen
- , Lei Cheng
- & Ming Li
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| Open AccessLevo-tetrahydropalmatine attenuates oxaliplatin-induced mechanical hyperalgesia in mice
- Zhenggang Guo
- , Yuanyuan Man
- & Weidong Mi
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| Open AccessTherapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria
- Virender Singh
- , Ratan Kumar Rai
- & Ashwani Kumar Thakur
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| Open AccessModular adeno-associated virus (rAAV) vectors used for cellular virus-directed enzyme prodrug therapy
- Sven Hagen
- , Tobias Baumann
- & Kristian M. Müller