Article
|
Open Access
Featured
-
-
Article
| Open AccessAn eco-friendly and cost-effective HPTLC method for quantification of COVID-19 antiviral drug and co-administered medications in spiked human plasma
- Ekram A. Ghozzy
- , Nahed M. El-Enany
- & Samah Abo El Abass
-
Article
| Open AccessPredicting FFAR4 agonists using structure-based machine learning approach based on molecular fingerprints
- Zaid Anis Sherwani
- , Syeda Sumayya Tariq
- & Zaheer Ul-Haq
-
Article
| Open AccessEpigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
- Zachary C. Rosenthal
- , Daniel M. Fass
- & Stephen J. Haggarty
-
Article
| Open AccessDevelopment of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state
- Yasuhiro Nakano
- , Eiko Saijou
- & Taketomo Kido
-
Article
| Open AccessDP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time
- Michael Kurz
- , Michaela Ulrich
- & Moritz Bünemann
-
Article
| Open AccessInferring molecular inhibition potency with AlphaFold predicted structures
- Pedro F. Oliveira
- , Rita C. Guedes
- & Andre O. Falcao
-
Article
| Open AccessAI is a viable alternative to high throughput screening: a 318-target study
- Izhar Wallach
- , Denzil Bernard
- & Abraham Heifets
-
Article
| Open AccessUltra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics
- Delia I. Fernández
- , Sara Troitiño
- & Johan W. M. Heemskerk
-
Article
| Open AccessCharacterization of human iPSC-derived sensory neurons and their functional assessment using multi electrode array
- Minami Hiranuma
- , Yuichi Okuda
- & Tomohisa Watanabe
-
Article
| Open AccessDigital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model
- Radina Kostadinova
- , Simon Ströbel
- & Mathieu Petitjean
-
Article
| Open AccessRestoring functional TDP-43 oligomers in ALS and laminopathic cellular models through baicalein-induced reconfiguration of TDP-43 aggregates
- Hsiang-Yu Chang
- & I-Fan Wang
-
Article
| Open AccessNovel antimicrobial peptides against Cutibacterium acnes designed by deep learning
- Qichang Dong
- , Shaohua Wang
- & Lun Yu
-
Article
| Open AccessHepa-ToxMOA: a pathway-screening method for evaluating cellular stress and hepatic metabolic-dependent toxicity of natural products
- Se-Myo Park
- , Mi-Sun Choi
- & Jung-Hwa Oh
-
Article
| Open AccessProcess optimization for green synthesis of silver nanoparticles using Rubus discolor leaves extract and its biological activities against multi-drug resistant bacteria and cancer cells
- Saeed Ghasemi
- , Sara Dabirian
- & Fatemeh Yousefbeyk
-
Article
| Open AccessHigh-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair
- Saurabh S. Dhakar
- , Albert Galera-Prat
- & Lari Lehtiö
-
Article
| Open AccessA scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compounds
- Kevin Lin
- , Ya-Chu Chang
- & Chad L. Myers
-
Article
| Open AccessBezafibrate attenuates immobilization-induced muscle atrophy in mice
- Satoshi Nakamura
- , Yuiko Sato
- & Takeshi Miyamoto
-
Article
| Open AccessBioadhesive behaviors of HPMC E5: comparative analysis of various techniques, histological and human radiological evidence
- Omar Y. Mady
- , Omar Dewedar
- & Yusuf Haggag
-
Article
| Open AccessComparative assessment of phenolic composition profile and biological activities of green extract and conventional extracts of Salvia sclarea
- Mohammed Mansour Quradha
- , Mehmet Emin Duru
- & Ozgur Ceylan
-
Article
| Open AccessA miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition
- Lilia Falkenstern
- , Victoria Georgi
- & Amaury Fernández-Montalván
-
Article
| Open AccessNetwork pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Radix Astragali against hypopharyngeal carcinoma
- Jianing Zhang
- & Lianhe Li
-
Article
| Open AccessNovel betulin derivatives as multidrug reversal agents targeting P-glycoprotein
- Jerónimo Laiolo
- , Dafni G. Graikioti
- & María C. Carpinella
-
Article
| Open AccessLimited high-throughput screening compatibility of the phenuivirus cap-binding domain
- Janna Scherf
- , Dominik Vogel
- & Maria Rosenthal
-
Article
| Open AccessTransfer learning for versatile and training free high content screening analyses
- Maxime Corbe
- , Gaëlle Boncompain
- & Auguste Genovesio
-
Article
| Open AccessNetwork pharmacology-based research on the effect of Radix Astragali on osteosarcoma and the underlying mechanism
- Yafang Zhang
- , Junqiang Wei
- & Yu Jin
-
Article
| Open AccessSemisynthesis of 5-O-ester derivatives of renieramycin T and their cytotoxicity against non-small-cell lung cancer cell lines
- Koonchira Buaban
- , Bhurichaya Innets
- & Supakarn Chamni
-
Article
| Open AccessStructure-based discovery of novel P-glycoprotein inhibitors targeting the nucleotide binding domains
- Laust Moesgaard
- , Maria L. Pedersen
- & Jacob Kongsted
-
Article
| Open AccessEvaluating the antioxidant potential of resveratrol-gold nanoparticles in preventing oxidative stress in endothelium on a chip
- Farzaneh Fayazbakhsh
- , Fatemeh Hataminia
- & Hossein Ghanbari
-
Article
| Open AccessHigh-throughput analysis system of interaction kinetics for data-driven antibody design
- Ryo Matsunaga
- , Kan Ujiie
- & Kouhei Tsumoto
-
Article
| Open AccessSynthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2,4-thiazolidinediones as partial PPAR-γ agonists
- Asim Najmi
- , Md Shamsher Alam
- & Faizul Azam
-
Article
| Open AccessArtificial axons as a biomimetic 3D myelination platform for the discovery and validation of promyelinating compounds
- Anna Jagielska
- , Kristin Radzwill
- & Krystyn J. Van Vliet
-
Article
| Open AccessTo investigate the mechanism of Yiwei Decoction in the treatment of premature ovarian insufficiency-related osteoporosis using transcriptomics, network pharmacology and molecular docking techniques
- Weisen Fan
- , Yan Meng
- & Xin Xiu
-
Article
| Open AccessThe anticancer and antibacterial potential of bioactive secondary metabolites derived From bacterial endophytes in association with Artemisia absinthium
- Mohammad Sadegh Damavandi
- , Hasan Shojaei
- & Bahram Nasr Esfahani
-
Article
| Open AccessMultiple green spectroscopic methods for erdosteine determination in bulk and dosage form with extensive greenness evaluation
- Hadeel A. Khalil
- , Eman I. El-Kimary
- & Tarek S. Belal
-
Article
| Open AccessUnlocking potential inhibitors for Bruton's tyrosine kinase through in-silico drug repurposing strategies
- Mohammed Alrouji
- , Lizy Sonia Benjamin
- & Atiya Akhtar
-
Article
| Open AccessComputational screen for sex-specific drug effects in a cardiac fibroblast signaling network model
- Kelsey M. Watts
- , Wesley Nichols
- & William J. Richardson
-
Article
| Open AccessIdentification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform
- Alexander Ernst
- , Indre Piragyte
- & Nadia Mercader
-
Article
| Open AccessDiscovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation
- Honami Echizen
- , Kenjiro Hanaoka
- & Yasuteru Urano
-
Article
| Open AccessSimultaneous LC–MS/MS method for the quantitation of Azithromycin, Hydroxychloroquine and its metabolites in SARS-CoV-2(−/ +) populations using dried blood spots
- Yashpal S. Chhonker
- , Wafaa N. Aldhafiri
- & Daryl J. Murry
-
Article
| Open AccessNew drug discovery of cardiac anti-arrhythmic drugs: insights in animal models
- Ashish Kumar Sharma
- , Shivam Singh
- & Arun Garg
-
Article
| Open AccessLabel-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography
- Ibrahim Abd El-Sadek
- , Larina Tzu-Wei Shen
- & Yoshiaki Yasuno
-
Article
| Open AccessNovel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties
- Motahareh Mortazavi
- , Masoomeh Eskandari
- & Omidreza Firuzi
-
Article
| Open AccessIdentification of potential new COVID-19 treatments via RWD-driven drug repurposing
- Yun Liao
-
Article
| Open AccessA multi-targeted computational drug discovery approach for repurposing tetracyclines against monkeypox virus
- Thamir A. Alandijany
- , Mai M. El-Daly
- & Esam I. Azhar
-
Article
| Open AccessIn vitro synergy screens of FDA-approved drugs reveal novel zidovudine- and azithromycin-based combinations with last-line antibiotics against Klebsiella pneumoniae
- Marta Gómara-Lomero
- , Ana Isabel López-Calleja
- & Santiago Ramón-García
-
Article
| Open AccessSubstituted salicylic acid analogs offer improved potency against multidrug-resistant Neisseria gonorrhoeae and good selectivity against commensal vaginal bacteria
- Hanan Almolhim
- , Ahmed E. M. Elhassanny
- & Paul R. Carlier
-
Article
| Open AccessGreen “turn-off” luminescent nanosensors for the sensitive determination of desperately fluorescent antibacterial antiviral agent and its metabolite in various matrices
- Hadil M. Elbardisy
- , Mai M. Elnaggar
- & Amira F. El-Yazbi
-
Article
| Open AccessEvaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model
- Tim Kaden
- , Katja Graf
- & Martin Raasch
-
Article
| Open AccessCisplatin exhibits superiority over MMC as a perfusion agent in a peritoneal mesothelioma patient specific organoid HIPEC platform
- Steven D. Forsythe
- , Richard A. Erali
- & Konstantinos I. Votanopoulos