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Genetics Generation
Moderated by  Laura Rivard
Posted on: June 26, 2013
  |  
Posted By: Laura Rivard

Case Study in GM Food Animals

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In September 2010, AquaBounty Technologies, and its product, AquAdvantage Atlantic salmon, garnered significant media attention when the FDA released a preliminary assessment finding the genetically modified fish safe for human consumption and unlikely to cause a significant environmental impact. This announcement was met with calls for further study since the original assessment was based on a small sample size. The story has since quietly slipped from the headlines, but the fish have not gone away. In December 2012, the FDA released their more extensive draft environmental assessment (EA), which again found that the fish are safe for human consumption and pose no environmental risk. A typical 60-day comment period followed the release of the EA to allow for public input. The FDA then extended the comment period an additional 60 days; the extended comment period ended April 26, 2013. The FDA has not yet made a final announcement, but many expect the salmon will be approved

If these fish make it to market, they will be the first genetically modified food animal available for human consumption. Genetically modified plants have been in the grocery store for over a decade. The top three genetically modified food crops are corn, soy, and canola. Unless you are buying strictly organic, you have almost certainly consumed a GM plant derivative, particularly in processed foods. GM corn, soy, and canola have been engineered for a) pest resistance, b) herbicide resistance (which allows farmers to spray with a broad-spectrum weed-killer called Roundup that would normally harm the crops), or c) both. AquAdvantage salmon have been genetically engineered to reach market weight in 18-months, as opposed to the three years it takes conventional salmon. So why do AquAdvantage salmon grow more quickly? Conventional salmon grow only during the warmer seasons of the year, but AquAdvantage salmon bypass this "problem" through the introduction of the Chinook salmon version of the growth hormone gene. The DNA introduced into the AquAdvantage salmon also contains a segment of regulatory DNA from a third fish, the ocean pout, which causes the Chinook growth hormone to be expressed year-round. It is unclear whether the FDA will recommend that the fish be labeled as genetically modified; no current laws will require it.

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From:  cypha brooklyn |  March 28, 2018
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I totally agree with your points on education. Science education is important and we should help our children more into practical education than theories. This helps them to learn themselves and get more ideas to develop their skills.

From:  cheapest cable tv providers in my area |  March 21, 2018
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This are what we call the change of naturally to artificiality, and I don't take anything made genetically artificial. Don't get me wrong, I believe in genetics but outside the body of human genetics is not a welcome idea for me. Upon the FDA continual claiming the safety of this product, detailed study might prove some side effects that are harmful to the human existence.

From:  Nana Mama |  July 7, 2013
Community

I agree with Henry Miller. I believe that we need to define our terms a a bit more precisely. It seems to me that "genetic engineering" and "genetically modified" may not denote the same techniques, and either procedure may or may not encompass Recombinant DNA. "Cross breeding" tangelos seems to be quite a different endeavor to genetically modifying animals.

In this regard, consider the reference made by Henry to Anonymous (1992) U.S. biotechnology policy. Nature 356, 1–2]. The statement made in the reference is that there is no conceptual difference between genetic modification by classical techniques and modern techniques of genetic modification was made 20 years ago. does it still apply? Also, even if there is no "conceptual difference," there could be significant differences in consequences of the use of the different methods.

From:  gary jones |  July 4, 2013
Community

Marcia, that makes much more sense. Thank you for clearing that up!

From:  Bruce Braun |  July 4, 2013
Community

@ Bruce Braun: To answer your question regarding possible variability using "the same genetic techniques ... to create the next 'batch'", the answer is no. Only the fish destined for commercial production would be reproductively sterile. To maintain their breeding program, AquaBounty Technologies would have to maintain a reproductively capable broodstock population (mature fish) for annual spawning. The fertilized eggs would then be subjected to the sterility treatment (triploidization via hydrostatic pressure shock) and shipped to a commercial rearing facility for grow-out.

From:  Marcia Chiasson |  July 3, 2013
Community

You've fallen into the trap of considering "genetic modification" or "genetic engineering" to be synonymous with recombinant DNA technology, although there's no scientific reason to do so. As Nature editorialized in 1992, a broad scientific consensus holds that "the same physical and biological laws govern the response of organisms modified by modern molecular and cellular methods and those produced by classical methods. . . . [Therefore] no conceptual distinction exists between genetic modification
of plants and microorganisms by classical methods or by
molecular techniques that modify DNA and transfer
genes." [Anonymous (1992) U.S. biotechnology policy. Nature 356, 1–2]

Also, consider the excerpt below from http://www.hoover.org/publications/defining-ideas/article/88906:

"Genetic engineering of food products is, in fact, old hat. Except for wild game, wild mushrooms, wild berries, and fish and shellfish, virtually all foods in the European and American diet have long been derived from modified organisms—even the organic food at Whole Foods and the local farmers market. Tangelos resulted from a genetic cross between tangerines and grapefruit, for example. Yogurt, beer, tofu, and bread are made with microorganisms that have been painstakingly modified and optimized over the centuries. Grains, in particular, have been intensively engineered over millennia for higher yields, pest- and disease-resistance, and various other desirable characteristics. For example, although modern wheat varieties vary widely in their traits and genetics, all are derived from a common precursor first domesticated in Turkey around 9,000 B.C., and which was subsequently genetically improved by farmers, plant breeders, and biologists. Current varieties include durum wheat for pasta and so-called common wheat for bread.

"Animals, too, have been genetically engineered, mostly by laborious and imprecise trial-and-error breeding techniques. The dozens of varieties of cattle raised today are all derived from the now-extinct auroch, which was used both for food and as a beast of burden from ancient times until the seventeenth century. A relatively recent new food animal, the "beefalo," is a cow-bison (buffalo) hybrid. It combines the superior hardiness, foraging ability, ease of calving, and low-fat meat of the bison with the fertility, milking ability, and docility of the cow."

From:  Henry Miller |  July 3, 2013
Community

Hm...genetically refining land-based aquaculture does seem like a good way to deal with the increasing global demand for fish products (while avoiding the dangers of overfishing that is), but...since all the fish are sterile, and the same genetic techniques would have to be applied to create the next 'batch' (I am not sure of how to properly phrase this), is there any chance in the variability of results? Do we know that it'll be the same, safe, fish every single time? Basically, is conceivable for an "error" in the process to creep in?

From:  Bruce Braun |  July 2, 2013
Community

I have big concerns about the ecological impact. But, AquaBounty says the fish will be raised strictly in land-based farms with little risk of escape. Additionally, the fish are all female and mostly sterile. So, if we take AquaBounty at its word (is this wise?), than the ecological impacts should be minimal. However, the non-scientist side of me is having a tough time with the thought of eating these fish. Something doesn't "feel" right to me. It seems like another example of first world countries trying to find another way to deal with our over-consumption of natural resources.

From:  Laura Rivard |  July 2, 2013
Community

Agree with Ilona here.

Also think it's important to know how the corporations around the salmons (and possible future GM animals) will go about promoting others to rear/cultivate their "creations." We really shouldn't let a GM plant/seeds fiasco happen again.

From:  Khalil A. Cassimally |  June 27, 2013
Community

NO idea. Here is what i would want to know to begin thinking about it

ENVT'L RISK: These genetically modified salmon are raised on farms, right? So any environmental impact would be if they were released/leaked into general population? Not sure how they assess the envt'l impact of this...

HUMAN SAFETY: We have no idea. But we eat GM content all the time. Have been for decades. Is it worse or better than growth hormone-injected beef? Is there a larger amount of growth hormone in the salmon we buy/ingest than in non GM salmon? Or is the increased presence of hormone only triggered to times during fish development --and otherwise no more growth hormone is in the meat than non-GM salmon, when consumed?

From:  Ilona Miko |  June 26, 2013
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