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Revascularization has a pivotal role in ischemic stroke therapy, and strokes involving small blood vessels respond well to intravenously administered thrombolytic drugs. Large-vessel strokes carry higher morbidity and mortality than small-vessel strokes, and are less amenable to thrombolytic approaches. In this Review, Wade Smith assesses recent data indicating that recanalization of large vessels can be achieved using mechanical clot retrieval devices.
Intravenous immunoglobulin has an important role in the treatment of numerous neuroimmunological disorders, including Guillain–Barré syndrome and multiple sclerosis. In this article, Gold et al. review current and future indications for intravenous immunoglobulin treatment, discuss its proposed mechanisms of action, and highlight various practical issues relating to its use in the clinic.
