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When designing neurotechnologies to assist people with communication disabilities, neuroscientists and engineers must consider both the speaker’s perspective and the listeners’ ability to judge the voluntariness and accuracy of decoded communication. This is particularly important in personally significant communication contexts for which there are profound legal and societal implications.
After establishing a novel operant conditioning paradigm that enables mice to report their interoceptive hunger state (fasted or sated), the authors investigated the hypothalamic neural circuitry that underpins these internal states using optogenetics and chemogenetics.
Reactivation of CaMKII–CREB signalling in retinal ganglion cells following injury is neuroprotective and restored functional vision following excitotoxic damage.
A neural manifold analysis reveals that the hippocampus encodes both spatial and learned abstract information from the environment in a conjoined cognitive map.
As has been shown for developing excitatory synapses, microglia regulate connectivity in developing inhibitory circuits via a complement- and GABAB1 receptor-dependent mechanism.
In individuals with schizophrenia, a reduced capacity to infer relationships between visual stimuli is associated with impaired spontaneous neural replay.