News & Comment

Endocannabinoid activation of astrocytic CB1Rs potentiates neurotransmission at synapses far away from the site of endocannabinoid release.

The functional integrity of the blood–brain barrier is regulated by pericytes during development and in adulthood.

Defects in the polyamine pathway, including aberrant spermidine/spermine N1-acetyltransferase 1 (SAT1) activity, may play a part in Parkinson's disease pathogenesis.

SSRIs are used to treat depression and have a delayed onset of action. The mechanism involves post-transcriptional regulation of a serotonin transporter in the raphe nucleus and the locus coeruleus.

A small molecule that increases endocannabinoid signalling at sensory nerve terminals enhances analgesia.

Hedgehog signalling establishes spatial correspondence between olfactory receptor neurons and their targets in the brain through a two-step mechanism.

Regional variations in aerobic glycolysis in young adults correlate spatially with amyloid-β deposition in older individuals.

DISC1 negatively regulates synaptic strength by inhibiting the TNIK-dependent stabilization of postsynaptic proteins.

EGFR–Notch 1 pathway interactions balance neural stem cell and progenitor cell populations.

Glutamate can facilitate inhibitory glycine receptor signalling in the spinal cord and brainstem through allosteric modulation.

Presynaptic GABA_Breceptors sense local variations in basal GABA levels and homeostatically regulate release probability at individual excitatory boutons.

Glia can discriminate patterns of synaptic activity and modulate synaptic plasticity through balanced A₁ and A₂adenosine receptor activation.

Transient receptor potential cation channel N1 is a mechanosensitive channel in fruitflies and nematode worms.

Exercise reduces food intake through an interleukin-6 (IL-6)-mediated mechanism acting in the hypothalamus.