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This PrimeView highlights the split-and-pool combinatorial chemistry construction of DNA-encoded chemical libraries for screening large numbers of compounds against druggable targets.
DNA-encoded chemical libraries (DECLs) are used in the discovery of small molecules with potential therapeutic benefit. In this Primer, Satz et al. describe the best practices for DECL synthesis, selection and analysis, as well as requirements to enhance reproducibility between and within groups.
This PrimeView highlights experimental design for using surface enhanced Raman spectroscopy (SERS) to boost Raman signals of test materials, with a focus on the synthesis of SERS-active substrates.
Surface-enhanced Raman spectroscopy (SERS) uses nanostructured materials to enhance the Raman scattering of a sample, enhancing sensitivity and allowing analysis of materials in low concentration. In this Primer, Han et al. detail the use of SERS equipment and preparation of SERS-active materials, as well as recent applications in biological and chemical sciences.
