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Volume 21 Issue 2, February 2023

The road ahead, inspired by the Review on p87.

Cover design: Philip Patenall.

Research Highlights

  • This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metabolism of Clostridioides difficile, enhancing its fitness and virulence.

    • Agustina Taglialegna
    Research Highlight

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  • This study reports that SARS-CoV-2 binds to cilia and reprogrammes microvilli to promote replication in the nasal airway.

    • Agustina Taglialegna
    Research Highlight
  • This study reports that mycobiota-derived metabolites can feed pathogenic Salmonella enterica subsp. enterica serovar Typhimurium and promote its competitive advantage, thus revealing a role of the fungal community during bacterial infection.

    • Andrea Du Toit
    Research Highlight
  • This study shows that commensal bacteria can degrade the intestinal extracellular matrix and contribute to colonic inflammation.

    • Agustina Taglialegna
    Research Highlight
  • This study identifies the eukaryotic commensal Entamoeba gingivalis as the main host for human-associated redondoviruses.

    • Agustina Taglialegna
    Research Highlight
  • Meyer et al. show that Toxoplasma gondii infection influences wolf behaviour in the wild, increasing risk-taking behaviours such as dispersing from a pack and becoming a pack leader.

    • Michael Attwaters
    Research Highlight
  • Wu et al. provide mechanistic insight into how the plant symbiotic fungus Metarhizium robertsii can reduce mercury accumulation in soil.

    • Michael Attwaters
    Research Highlight
  • Arevalo et al. have developed a nucleoside-modified mRNA-lipid nanoparticle vaccine encoding separate haemagglutinin antigens from all known influenza virus subtypes.

    • Michael Attwaters
    Research Highlight
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News & Analysis

  • This Genome Watch article explores how portable sequencing technology is re-shaping the field of genomic epidemiology.

    • Catherine N. Wilson
    • Patrick Musicha
    • Mathew A. Beale
    Genome Watch
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Reviews

  • In this Review, Flemming et al. revisit our understanding of the biofilm matrix, focusing on the diversity of the extracellular polymeric substance components and novel aspects of mechanisms and consequences of their functional interactions.

    • Hans-Curt Flemming
    • Eric D. van Hullebusch
    • Stefan Wuertz
    Review Article
  • Lassa fever is a viral haemorrhagic fever that spills over from its rodent reservoir. Continued viral evolution and increasing exposure make Lassa virus a high-risk pathogen. In this Review, Garry highlights new insights into the virology, disease presentation and potential countermeasures.

    • Robert F. Garry
    Review Article
  • In this Review, Severn and Horswill highlight new developments in our understanding of Staphylococcus epidermidis strain diversity, skin colonization dynamics and its multifaceted positive and negative interactions with the host and other members of the skin microbiota during skin colonization or infection.

    • Morgan M. Severn
    • Alexander R. Horswill
    Review Article
  • In this Review, Carabelli, Robertson and colleagues explore data on the neutralization of globally circulating variants of concern by monoclonal antibodies (mAbs) and discuss how knowledge of the dynamics of viral evasion of mAbs can contribute to viral surveillance and the development of novel mAb treatments, as well as inform predictions of resistance that may arise in the future.

    • MacGregor Cox
    • Thomas P. Peacock
    • Alessandro M. Carabelli

    Series:

    Review Article
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