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This study identifies the Mycobacterium tuberculosis effector protein PtpB and shows that it counteracts gasdermin D-mediated pyroptosis and inflammatory cytokine release by altering the phospholipid composition of the host membrane.
This study reports the identification of a highly divergent lineage of SARS-CoV-2 in white-tailed deer and provides evidence of deer-to-human transmission.
A recent study reports that nicotine accumulates in the gut during smoking and promotes the progression of non-alcoholic fatty liver disease, and shows that the gut bacterium Bacteroides xylanisolvens can degrade nicotine.
In this study, a multinational and multidisciplinary panel of experts provides actionable recommendations for policy makers to end the COVID-19 pandemic.
A new study identified two distinct lineages of monkeypox virus (MPXV) in the United States with evidence of genome editing by host apolipoprotein B editing complex (APOBEC3) cytosine deaminase, which might be accelerating MPXV evolution.
A recent study used a zebrafish model to show that the microbiota promotes social behaviour by stimulating microglial pruning of brain circuits during early neurodevelopment.
This month’s Genome Watch highlights how genome sequencing can be used to understand the strain-level diversity, evolution and spatial structure of the human microbiome, and to inform therapeutic strategies.
One health links human, animal and environmental health, and microorganisms have a central role in this connection. In this Review, Banerjee and van der Heijden outline the central role of the soil microbiome for one health and its detrimental or beneficial effects.
In this Review, Brouns and colleagues discuss our current understanding of RNA-targeting type III and type VI CRISPR–Cas systems by detailing their composition, properties and defence processes, and describing the biological rationale behind the broad activated immune responses as an effective strategy to combat viral infection.
In this Review, Gilbert and colleagues discuss recent progress in drug discovery for kinetoplastid diseases and how an improved understanding of parasite biology affects the drug discovery process
Epstein–Barr virus infects most of the human population and, depending on other risk factors, contributes to the development of multiple sclerosis. In this Review, Soldan and Lieberman discuss supporting evidence and potential mechanisms that link Epstein–Barr virus to multiple sclerosis.
