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Synthetic biology approaches for thede novodesign of biosynthetic pathways have developed rapidly in recent years. Takano and colleagues describe the latest computational tools available and discuss how they can be applied now and further developed for future synthetic biology efforts.
Some individuals who are infected with both HIV and an opportunistic pathogen develop immune reconstitution inflammatory syndrome (IRIS) when CD4+T cell numbers are restored. This reaction may arise from a hyper-responsiveness of innate immune cells to the newly reconstituted T cell help, and may apply to other cases of inflammatory pathology.
Justin Radolf and colleagues summarize our accumulated knowledge of the molecular biology and virulence ofBorrelia burgdorferi, and its interactions with the arthropod vector and mammalian hosts.
