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  • This study shows that targeting the microbiota enzymes that are involved in the production of trimethylamine (TMA) reduces the levels of TMAN-oxide (TMAO) and is a potential therapeutic strategy for cardiovascular disease.

    • Cláudio Nunes-Alves
    Research Highlight
  • The analysis of mammalian genomes provides new insights into the interactions of endogenous retroviruses with other viruses and their hosts.

    • Astrid Gall
    Genome Watch
  • This study shows that herpes simplex virus hijacks a neuron-specific JNK stress response pathway to reactivate the expression of latent virus.

    • Ursula Hofer
    Research Highlight
  • Two recent studies have shown that someNitrospiraspecies can oxidize ammonia to nitrite and nitrite to nitrate, demonstrating that the two steps of nitrification can be carried out by single microorganisms.

    • Cláudio Nunes-Alves
    Research Highlight
  • Two new studies show that Hsp70 inhibitors are promising candidates as antivirals against flaviviruses, including dengue virus (DENV), and Kaposi's sarcoma-associated herpesvirus (KSHV).

    • Naomi Attar
    Research Highlight
  • This study investigates the links between diet, the gut microbiota and postprandial glycaemic responses (PPGRs), showing that differences in the gut microbiota are associated with the high interpersonal variability in the PPGRs to identical meals.

    • Cláudio Nunes-Alves
    Research Highlight
  • This study identifies two new polyketide metabolites ofClostridium puniceumthat enable this crop pathogen to thrive in its unusual aerobic niche while inhibiting the growth of other bacteria.

    • Ursula Hofer
    Research Highlight
  • Functional genomics has helped to identify global regulators of sexual differentiation in the malaria parasite.

    • Ana Rita Gomes
    • Arthur M. Talman
    Genome Watch
  • Two X-ray crystallography studies reveal the mechanism underlying spacer acquisition by CRISPR−Cas systems.

    • Naomi Attar
    Research Highlight
  • This study shows that processing of merozoite surface protein 1 (MSP1) by thePlasmodiumsubtilisin-like serine protease SUB1 enables MSP1 to interact with the host cell cytoskeleton, enabling parasite egress from red blood cells.

    • Denise Waldron
    Research Highlight