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  • Vibrio parahaemolyticusVPA0450 contributes to host cell death by interfering with phosphatidylinositol signalling.

    • Rachel David
    Research Highlight

  • The vitamin B6-dependent glycosylation of flagella is required for full Helicobacter pylorimotility and virulence.

    • Sheilagh Molloy
    Research Highlight

  • EHEC and EPEC produce large macromolecular structures that exhibit adhesive and cytopathic properties and might act as a substratum for biofilm formation.

    • Andrew Jermy
    Research Highlight

  • A recentPLoS Pathogenspaper provides direct evidence to support the hypothesis that the systemic immune activation that occurs during chronic HIV-1 infection is linked to the translocation of microbial products from the intestinal lumen.

    • Sheilagh Molloy
    Research Highlight

  • Bacillus subtilisuses a ruler-like mechanism to sense temperature according to membrane thickness.

    • Lucie Wootton
    Research Highlight

  • TRIM5α can restrict the spread of SIV in a natural setting, as it does in cell culture.

    • Christiaan van Ooij
    Research Highlight

  • This month's Genome Watch discusses ways to automatically produce 'base-perfect' genome sequences.

    • Thomas D. Otto
    Genome Watch

  • Our monthly round up of infectious diseases news, which this month includes an antisense therapy for Ebola virus infection, a transcriptional signature for active tuberculosis, and the spread of carbapenem antibiotic resistance.

    Disease Watch

  • World Rabies Day, on 28 September, focuses our attention on a horrific, preventable disease that still kills tens of thousands of people each year.

    Editorial

  • A type III secretion system effector produced byChlamydia trachomatisis targeted to the nucleus of the host cell and functions as a histone methyltransferase.

    • Andrew Jermy
    Research Highlight

  • A new report shows that phosphorylation of eukaryotic translation initiation factor 2α regulates the conversion ofPlasmodiumspp. salivary gland sporozoites into liver-stage sporozoites.

    • Sheilagh Molloy
    Research Highlight

  • Extracellular DNA binds to the holdfast ofCaulobacter crescentusswarmer cells, promoting biofilm dispersal.

    • Andrew Jermy
    Research Highlight

  • Two recent papers show that PD1 has a key role in regulating the innate immune response toMycobacterium tuberculosisinfection.

    • Sheilagh Molloy
    Research Highlight

  • Baculoviruses migrate intracellularly using actin-based motility.

    • Rachel David
    Research Highlight

  • Changing growth phases, signalled through the TCA cycle, induces a switch from the pathogenic state to the mutualistic state in a symbiont.

    • Christiaan van Ooij
    Research Highlight