Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The realization that there is structural similarity between viruses that infect all three domains of life has led to calls for additions to the way in which the virosphere is classified. In this Opinion, the vertical β-barrel viral lineage is used as an example to support reclassification of viruses into superlineages.
The human gut microbiota contain health-promoting indigenous species (probiotic bacteria) that are commonly consumed as live dietary supplements. The genomics of probiotic bacteria — or probiogenomics — could shed light on how beneficial gut bacteria adapt to the gut environment and promote better gut health.
In this Review, the authors evaluate the strategies that the intracellular pathogenLegionella pneumophilauses to establish growth inside cells and probe why this microorganism has accumulated an unprecedented number of translocated substrates that are targeted to host cells.
The outer membrane of Gram-negative bacteria contains many protein channels, called porins. These channels mediate the influx of various compounds, including antibiotics. Adaptations that reduce influx contribute to the emergence and dissemination of antibiotic resistance. This Review outlines recent advances in our understanding of the physico-chemical parameters that govern antibiotic translocation through porin channels.
The vast resource of viral genome sequences has been exploited to carry out a genomic comparison and phylogenetic analysis of the picorna-like superfamily. The authors conclude that the diverse groups of picorna-like viruses probably evolved in a 'Big Bang' that came after the evolution of the main groups of eukaryotes.