Articles in 2016

Genome analysis of 38 differentLegionellaspecies has identified a vast repertoire of effectors, many of which are species-specific and were probably acquired from amoeba hosts or co-infecting pathogens.

African trypanosomes produce extracellular membrane vesicles that transfer virulence factors to neighbouring parasites and host cells.

This study examines how bacteria fine-tune quorum sensing activity to adapt group behaviours such as biofilm formation to local flow conditions.

Advances in whole-genome sequencing have enabled within-host genome evolution to be studied with unprecedented detail. In this Review article, Didelot, Wilson and colleagues discuss how these studies have altered our view of host adaptation and antibiotic resistance during bacterial infection.

Transposon insertion sequencing (TIS) enables genome-wide definition of loci that are required for growth in diverse conditions. In this article, Waldor and colleagues discuss the benefits and limitations of different experimental approaches to TIS analyses.

An increasing number of countries in the Americas are reporting cases of Zika virus.

A genetic suppressor screen inEscherichia coliidentifies the methionine sulfoxide reductase that repairs proteins in the cell envelope, in a mechanism that uses the respiratory chain as a novel source of electrons.

Although the mechanisms of CRISPR–Cas interference have largely been elucidated, how new sequence memories are stored had remained unknown. In this Progress article, Amitai and Sorek discuss recent advances in the study of this adaptation stage of CRISPR immunity.