Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
In this Comment article, the authors argue that recent reports showing effects of sodium on cellular immunometabolism support an expansion of the definition of salt sensitivity beyond effects on blood pressure.
Probiotic gut bacteria can translocate to and persist in melanomas where they stimulate antitumour CD8+ T cells through the production of immunomodulatory metabolites.
Copper(ii) ions promote the metabolic and epigenetic remodelling of macrophages towards a pro-inflammatory state. A copper-binding metformin dimer showed promising results in mouse models of inflammation.
A preprint by Rodríguez-Silvestre et al. describes a mechanism for the export of antigens from endosomes regulated by perforin 2, for cross-presentation by dendritic cells.
A preprint by Mahadevan et al. shows that pancreatitis alters the immune landscape of mice with pancreatic ductal adenocarcinoma and highlights a role for dendritic cells in promoting responses to immune checkpoint blockade.
In this Review, the authors consider the many diverse ways in which the cytokine transforming growth factor-β (TGFβ) can regulate immune responses to tumours. Despite its complex roles, therapies are being developed that target TGFβ for cancer therapy, and the authors discuss the potential of these.
This Review discusses recent applications of CRISPR screening to discover intracellular and intercellular regulators of immune cell function in infection, inflammation and cancer, with a focus on the advances of in vivo and single-cell CRISPR screens in immuno-oncology.
In addition to antibody-mediated neutralization, Fc-dependent effector functions of antibodies directed to SARS-CoV-2 are emerging as an important factor in determining the outcome of infection. This Review highlights the current state of the field and discusses remaining uncertainties regarding Fc-dependent, non-neutralizing functions of antibodies.
In this Perspective, Alain Fischer reflects on the development of gene therapy for patients with inborn errors of immunity. He discusses the challenges the field has faced as well as the progress seen in the past 25 years.
